Publications by authors named "Hitoshi Ogata"

Background: Preterm infants discharged from the neonatal intensive care unit (NICU) have a risk of severe viral respiratory tract infections (RTIs). Researchers have recently reported the potential use of postbiotics to decrease RTIs in young children. However, the safety and efficacy of postbiotics for preventing RTIs in preterm infants is not yet established.

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Single-strain species are commonly used as probiotics with low birth weight neonates. However, the effectiveness and safety of multi-strain supplementation are not well known. Thirty-six neonates weighing less than 2,000 g (558-1,943 g) at birth and admitted to a neonatal intensive care unit were randomly assigned to receive a single strain or triple strains of with lactulose enterally for 4 weeks from birth.

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Article Synopsis
  • Ozoralizumab is a new trivalent, bispecific NANOBODY that shows promise for treating rheumatoid arthritis (RA) without causing anti-drug antibodies (ADAs), which can lead to treatment failure with traditional anti-TNFα antibodies.
  • In experiments with human TNF transgenic mice, ozoralizumab significantly reduced arthritis progression and did not induce ADAs during long-term use.
  • Switching from adalimumab, a typical anti-TNFα IgG known for losing effectiveness over time, to ozoralizumab resulted in better results in an animal model of treatment failure, highlighting ozoralizumab's potential for RA patients facing secondary treatment failure.
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Panton Valentine Leukocidin (PVL) is one of the many toxins produced by Staphylococcus aureus. In Japan, PVL-positive S. aureus strains are mainly methicillin-resistant S.

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Osteoclasts are multinucleated cells responsible for bone resorption. The differentiation of osteoclasts from bone marrow macrophages (BMMs) is induced by receptor activator of NF-κB ligand (RANKL). Osteoprotegerin (OPG), a decoy receptor of RANKL, inhibits osteoclastogenesis by blocking RANKL signaling.

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A case in which radiotherapy was requested for bone metastases from prostate carcinoma after hormonal and radiation therapy and diagnosed as insufficiency fracture of the sacrum on bone scan was reported. A 78-year-old man underwent endocrine therapy with luteinizing hormone releasing hormone agonists and radical radiotherapy toward pelvis for prostate cancer. The onset of buttock pain started from the nine-month after the beginning of radiotherapy, and was diagnosed as sacrum metastasis by MRI, and radiotherapy was requested again for pain control.

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Purpose: To determine whether the injection rate of contrast agent affects the dynamics of enhancement of the pulmonary parenchyma on magnetic resonance (MR) pulmonary perfusion imaging.

Materials And Methods: Fifteen healthy volunteers underwent enhanced MR pulmonary perfusion imaging to evaluate the effects of different injection rates. Injection rates were 1, 3, or 5 mL/second.

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