Publications by authors named "Hitoshi Hino"
Article Synopsis
- The study focuses on identifying prognostic factors affecting unresectable recurrence-free survival (URFS) in patients with resectable colorectal liver-only metastasis (CRLOM).
- Researchers analyzed data from 101 patients who underwent curative surgeries and emphasized the role of molecular profiling and pre-surgery factors.
- Significant predictors of URFS included specific mutations in KRAS and RYR2, as well as elevated CA19-9 levels and advanced tumor stage.
Article Synopsis
- * A total of 189 patients who underwent total mesorectal excision and LLND were included, and data on local recurrence (LR) and lateral lymph node recurrence (LLNR) were analyzed after matching similar patient characteristics.
- * While 39 patients had pathological LLNM, the analysis showed similar rates of LR and LLNR in both groups after balancing their characteristics, suggesting LLND can provide comparable local control regardless of LLNM presence.
Background: The optimal approach for ensuring both complete resection and preservation of anal function in rectal gastrointestinal stromal tumor (GIST) remains unknown. The aim of this study was to clarify short-term and long-term outcomes after robotic radical surgery for rectal GIST.
Methods: A total of 13 patients who underwent robotic radical surgery for rectal GIST between December 2011 and April 2022 were included.
Background: Stoma prolapse (SP) is a common stoma-related complication, particularly in loop colostomies. This study aimed to investigate potential risk factors for SP development after laparoscopic loop colostomy.
Methods: In total, data from 140 patients who underwent laparoscopic loop colostomy were analyzed between September 2016 and March 2022.
Article Synopsis
- The study investigates the relationship between molecular profiles of rectal cancer and the occurrence of lateral lymph node metastasis (LLNM).
- Researchers analyzed data from 123 patients who underwent surgery for rectal cancer, finding that while mutation rates in key genes were similar between those with and without LLNM, a specific consensus molecular subtype (CMS4) was more prevalent in the LLNM-positive group.
- The findings suggest that lymph node size (≥6.0 mm) and CMS4 are strong indicators of LLNM, with their combination offering a high sensitivity for diagnosis.
Objectives: Preventing anastomotic complications during rectal cancer surgery is important. Compared with a manual circular stapler, a powered circular stapler is expected to reduce undesirable tension during anastomosis. However, whether a powered circular stapler can reduce anastomotic complications during robotic low anterior resection (Ro-LAR) remains unclear.
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- The study investigates the relationship between mesorectal fat area (MFA) and recurrence rates after robotic total mesorectal excision (TME) for rectal cancer.
- It was found that a smaller MFA is linked to worse relapse-free survival (RFS) rates, indicating it could be a key prognostic factor.
- In the patient group analyzed, those with MFA less than 19.7 cm had a significantly lower 5-year RFS compared to those with a larger MFA, highlighting its importance in cancer prognosis.
Article Synopsis
- * Fusion genes were found in 2% of cases, with RSPO fusions being the most prevalent at 1.5%, while other fusions were extremely rare.
- * RSPO fusion-positive patients showed higher recurrence rates compared to those without RSPO fusions, suggesting that these fusions may help identify patients at greater risk and inform treatment options.
Purpose: The purpose of this study was to evaluate the long-term outcomes of robotic rectal cancer surgery and to examine the risk factors for recurrence.
Methods: In a high-volume center in Japan, we retrospectively enrolled patients with pStage I-III rectal cancer within 15 cm of the anal verge who underwent robotic surgery from 2011 to 2017. Almost all patients underwent upfront surgery, and lateral lymph-node dissection (LLND) was performed for patients with locally advanced lower rectal cancer.
Aim: The aim of this work was to investigate the risk factors associated with the incidence of sexual dysfunction in patients who underwent robot-assisted surgery with several treatment options, such as neoadjuvant chemoradiotherapy and lateral lymph node dissection, and clarify the longitudinal course of erectile function in risk groups.
Method: A total of 203 male patients who underwent robot-assisted total mesorectal excision for rectal cancer between 2013 and 2019 were included. The risk factors for erectile and ejaculatory dysfunction as well as the longitudinal course of erectile function were retrospectively investigated in all cohorts and several risk groups, including those who underwent neoadjuvant chemoradiotherapy, lateral lymph node dissection and adjuvant chemotherapy.
Article Synopsis
- This study investigates whether a single surgeon can perform two laparoscopic colectomies (LCs) for colon cancer on the same day without affecting patient outcomes.
- The research involved analyzing data from patients at the Shizuoka Cancer Center, comparing those who had LCs as their surgeon's first vs. second surgery of the day, and employing propensity score matching for fair comparisons.
- Findings showed no significant differences in postoperative complications or long-term survival outcomes between the two groups, indicating that performing two LCs in one day is a feasible practice.
Article Synopsis
- Transcriptome-based classification is being considered for colorectal cancer (CRC) to better understand the relationship between molecular profiles and existing tumor markers like blood carcinoembryonic antigen (CEA).
- More than 1,500 Japanese CRC patients were grouped into five subtypes based on consensus molecular subtyping (CMS), revealing distinct characteristics in tumors that didn't fit traditional classifications.
- For CMS4 stage III CRC patients, high blood CEA levels may indicate a more aggressive disease, suggesting that combining molecular profiling with classical markers could enhance treatment decisions and insights into tumor immunity.
Purpose: The number of patients undergoing additional surgery after endoscopic resection (ER) for T1 colorectal cancer (CRC) is increasing. Regarding high-risk histology of lymph node metastasis (LNM) in T1 CRC, a submucosal invasion depth ≥ 1000 μm (T1b) alone may be related to a low incidence of LNM. This study was conducted to clarify the incidence of LNM and to identify factors associated with LNM in T1 CRC with high-risk histology characterized only by T1b.
View Article and Find Full Text PDFAim: Sphincter-preserving operations for ultra-low rectal cancer include low anterior and intersphincteric resection. In low anterior resection, the distal rectum is divided by a transabdominal approach, which is technically demanding. In intersphincteric resection, a perineal approach is used.
View Article and Find Full Text PDFBackground: According to Japanese guidelines, D2 or D3 lymph node dissection (LND) is indicated for cT2N0M0 colorectal cancer (CRC). In this study, we retrospectively compared the long-term outcomes between D2 and D3 LND among patients with cT2N0M0 CRC.
Methods: Our sample included 515 patients from the Japanese Study Group for Postoperative Follow-Up of Colorectal Cancer database, who underwent surgical resection for cT2N0M0 CRC between January 2009 and December 2012, 195 (37.
Article Synopsis
- The study aimed to compare the genetic characteristics of rectal cancer (RC) based on tumor location, focusing specifically on low rectal cancer (low RC) versus other types.
- Genetic analyses from 611 patients revealed that low RC had higher KRAS mutation rates and distinct gene expression levels compared to other RCs, showing significant differences in several genetic markers.
- Low RC also displayed a higher prevalence of fusion genes and distinct consensus molecular subtype (CMS) distributions, with CMS4 linked to poorer prognosis, suggesting different biological behaviors that could inform future treatment strategies.
Article Synopsis
- The study aimed to determine how the size of metastatic lymph nodes affects long-term outcomes in patients with stage III colon cancer who underwent potentially curative surgery.
- Researchers categorized 209 patients based on the size of the largest metastatic lymph node, finding that smaller nodes were linked to better survival rates after 5 years.
- Results showed that patients with the largest nodes (≥15 mm) had significantly worse recurrence-free survival, indicating that larger metastatic lymph nodes could serve as a negative prognostic indicator in colon cancer.
Aim: Accurate preoperative diagnosis of lateral lymph node metastasis (LLNM) from lower rectal cancer is important to identify patients who require lateral lymph node dissection (LLND). We aimed to create an effective prediction model for LLNM using machine learning by combining preoperative information.
Methods: We retrospectively examined patients who underwent primary rectal cancer surgery with unilateral or bilateral LLND between April 2010 and March 2020 at a single institution.
Purposes: The relationship between the general condition and long-term prognosis in elderly patients with colorectal cancer (CRC) undergoing curative surgery remains unclear. This study investigated the risk factors for poor long-term outcomes in elderly patients with CRC.
Methods: Data of pStage I to III patients with CRC ≥ 80 years old who underwent curative surgery were collected from a multi-institutional database of the Japanese study group for postoperative follow-up of CRC.
Purpose: Rectal cancers pose a threat to the mesorectal fascia or invade neighboring structures or organs. Some tumors are potentially resectable but are likely to be positive at the resection margin for cancer involvement and are thus recognized as "borderline resectable (BR)" tumors. This study aimed to clarify the short- and long-term outcomes of neoadjuvant chemoradiotherapy (nCRT) for BR low rectal cancer at a single Japanese center.
View Article and Find Full Text PDFPurpose: There are no established treatment strategies for patients with hepatic and pulmonary metastases at the time of primary colorectal cancer (CRC) diagnosis. This study assessed patients undergoing complete resection of primary CRC and hepatic and pulmonary metastases, to evaluate long-term outcomes and clarify clinicopathological factors associated with failure of complete resection.
Methods: This retrospective analysis enrolled patients at Shizuoka Cancer Center between 2002 and 2018 who underwent colorectal resection with curative intent for primary CRC with hepatic and pulmonary metastases.
Purpose: Although robotic surgery for rectal cancer can overcome the shortcomings of laparoscopic surgery, studies focusing on abdominoperineal resection are limited. The aim of this study was to compare the operative outcomes between robotic and laparoscopic abdominoperineal resection.
Methods: This retrospective cohort study was conducted from April 2010 to March 2020.
. The optimal radical surgical approach for rectal neuroendocrine tumor (NET) is unknown. .
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- The study aimed to assess the impact of robotic staplers on the occurrence of symptomatic anastomotic leakage in patients undergoing robotic low anterior resection for rectal cancer.
- A total of 427 patients were analyzed, out of which 168 pairs of cases using manual and robotic staplers were compared after matching for similar characteristics.
- Results showed that the rate of anastomotic leakage was significantly lower with robotic staplers (1.2%) compared to manual staplers (6.5%), highlighting robotic staplers as beneficial in reducing leakage risk.
We present a very rare case of rectal cancer in a patient with situs inversus totalis (SIT), which is a complete transposition of the thoracic and abdominal viscera. A woman in her 60s visited a local hospital reporting bloody stool and was diagnosed with upper rectal cancer and SIT. We made careful preoperative preparations for the congenital anomaly, and robotic-assisted high anterior resection with D3 lymph node dissection was performed.
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