Publications by authors named "Hitoshi Hamamura"

Background: There is little data on the association between the lower nutrition represented by serum albumin levels and related factors in a general population. The present study aimed to determine whether the albumin level positioned as some kind of biomarker with frailty measures, trace elements, and an inflammation marker.

Methods: In 2018, we performed an epidemiological survey in 1368 subjects who resided in Tanushimaru, Japan, in which we examined the blood chemistry including albumin, trace elements, hormone levels, and carotid ultrasonography.

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Article Synopsis
  • This study explores the relationship between elevated levels of homocysteine (Hcy) and asymmetric dimethylarginine (ADMA) and the risk of all-cause mortality in a general population.
  • Conducted over a 20-year period with 517 participants in Japan, it found a significant association between high Hcy levels and increased death rates, with elevated Hcy and ADMA showing a synergistic effect.
  • The findings are noteworthy as it's the first study to simultaneously measure Hcy and ADMA levels in this group, highlighting their combined impact on mortality risk.
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Aim: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been identified as an important regulator of low-density lipoprotein (LDL) receptor processing. Evolocumab and alirocumab are PCSK9 inhibitors; however, little is known about the association between PCSK9 levels and lipid profiles in a general population. Because PCSK9 inhibitors have LDL-C lowering effects, we investigated whether there is a positive correlation between serum PCSK9 levels and LDL-C or lipoprotein(a) [Lp(a)].

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Insulin-like growth factors are polypeptides, with arrays similar to insulin, and insulin-like growth factor 1 (IGF-1) is secreted via stimulation by growth hormone (GH) in the liver. The lack of both GH and IGF-1 leads to physiological age-related changes in the cardiovascular system; however, the role of IGF-1 and GH in hypertension has not been fully elucidated. Thus, we examined the association between plasma IGF-1 and GH levels and hypertension.

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We investigated the relationship between time trends in nutrient intake and coronary risk factors/mortality rates in Tanushimaru, a Japanese cohort of the Seven Countries Study. All men between the ages of 40 and 64 were enrolled. Subjects numbered 628 in 1958, 539 in 1977, 602 in 1982, 752 in 1989, 402 in 1999, 329 in 2009, and 160 in 2018.

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It is well known that subjects with metabolic syndrome show an elevated resting heart rate. We previously reported that elevated heart rate was significantly related to all-cause mortality, and that coffee consumption was inversely associated with metabolic syndrome. We hypothesized that higher coffee consumption may decrease all-cause mortality by reducing resting heart rate.

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Article Synopsis
  • A study conducted in Uku, Nagasaki, Japan, involving 445 residents, examined the relationship between serum TSP-2 levels and various health risk factors through blood tests and statistical analysis.
  • Findings showed that TSP-2 levels correlated significantly with factors like plasma glucose, insulin resistance, inflammation markers, and history of heart-related conditions, highlighting its potential role in predicting heart disease in the general population.
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Aims: It is well known that a decline in physical activity is associated with an increase of all-cause death including cardiovascular events and cancer. Few studies have examined the association between occupational sitting time and mortality. Therefore, we investigated this issue in a general population.

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