Publications by authors named "Hitomi Tamura"
Article Synopsis
- The study aimed to assess the safety and effectiveness of a new transanal tube (TAT) designed to prevent anastomotic leakage after low anterior resection (LAR) for rectal cancer.
- A total of 115 patients participated in a trial across multiple cancer centers, with a primary focus on measuring symptomatic leakage rates and associated complications from the TAT.
- Results showed a low leakage rate of 5.2%, significantly below the target threshold, indicating that the TAT is both safe and effective compared to previous methods.
Background: This is a phase 2 study aimed at evaluating the efficacy and safety of TAS-114, a novel deoxyuridine triphosphatase inhibitor, combined with S-1 in patients with advanced gastric cancer (AGC).
Methods: Eligible patients had AGC with measurable lesions, according to the Response Evaluation Criteria in Solid Tumors (RECIST, v1.1), with two or more previous chemotherapy regimens including fluoropyrimidines, platinum agents, and taxanes or irinotecan.
Article Synopsis
- A phase Ib trial evaluated the combination of regorafenib and nivolumab for treating gastric and colorectal cancer, focusing on finding the maximum tolerated dose.
- Fifty patients, who had undergone multiple previous chemotherapies, were treated, with varying results in terms of adverse effects and tumor response.
- The findings suggested that regorafenib at a dose of 80 mg combined with nivolumab showed manageable side effects and promising anti-tumor activity, indicating the need for further research with larger groups.
In this paper, we focus on the problem of tracking a moving target in a wireless sensor network (WSN), in which the capability of each sensor is relatively limited, to construct large-scale WSNs at a reasonable cost. We first propose two simple multi-point surveillance schemes for a moving target in a WSN and demonstrate that one of the schemes can achieve high tracking probability with low power consumption. In addition, we examine the relationship between tracking probability and sensor density through simulations, and then derive an approximate expression representing the relationship.
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- Leukocyte adhesion to endothelial cells is crucial in the early phase of endotoxin shock, and reducing this response may help prevent further organ damage.
- N-acetyl-cysteine (NAC) has shown potential in reducing endotoxin-induced changes, specifically by inhibiting the increase of CD11b expression in a dose-dependent manner.
- While NAC effectively reduced CD11b levels in response to lipopolysaccharide (LPS) and interleukin-8 (IL-8), it did not impact the decrease of CD62L expression caused by LPS.