Publications by authors named "Hitomi Okubo"

Objective: To quantify the association between a combination of modifiable prepregnancy lifestyle factors and the risk of adverse pregnancy outcomes (APOs).

Design: Prospective cohort study.

Setting: The Japan Environment and Children's Study.

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Background: Little is known about the relationship of healthy diets, which are widely recommended to prevent diseases in general populations, with the risk of hypertensive disorders of pregnancy (HDP), particular among non-Western populations with different dietary habits. We aimed to investigate the association between periconceptional diet quality and the risk of HDP among pregnant Japanese women.

Methods And Results: Dietary intake over 1 year before the first trimester of pregnancy was assessed using a validated, self-administered food frequency questionnaire among 81 113 pregnant Japanese women who participated in a prospective cohort of the Japan Environment and Children's Study.

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The current prebirth cohort study investigated the association between maternal intake of specific types of fatty acids during pregnancy and adolescent depressive symptoms based on the Center for Epidemiologic Studies Depression Scale. Subjects were 873 mother-child pairs. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire.

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Objectives: Nuts are nutrient-dense foods rich in unsaturated fatty acids, protein, dietary fiber, vitamins, and minerals. The present prebirth cohort study examined the association between maternal nut intake during pregnancy and the risk of childhood behavioral problems in 5-year-old Japanese children.

Methods: Study subjects were 1199 mother-child pairs.

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Background And Aim: Although diet is one of the potential environmental factors affecting ulcerative colitis (UC), evidence is not sufficient to draw definitive conclusions. This Japanese case-control study examined the association between the consumption of coffee, other caffeine-containing beverages and food, and total caffeine and the risk of UC.

Methods: The study involved 384 UC cases and 665 control subjects.

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Article Synopsis
  • The study investigates how a mother's diet before conception affects wheezing patterns in young children.
  • Researchers analyzed data from over 70,000 mother-child pairs to identify four distinct wheeze trajectories from ages 1 to 4.
  • A higher quality diet in mothers was linked to a lower chance of children experiencing "transient early" and "persistent" wheezing, suggesting that improving maternal nutrition could benefit child respiratory health.
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Purpose: Individuals with impaired masticatory function tend to prefer soft foods, which results in decreased masticatory muscle activity. This study examined the association between the oral condition (number of teeth, occlusal force, and occlusal contact area) and dietary hardness using a daily dietary questionnaire.

Methods: This cross-sectional study evaluated 1841 participants aged 69-71 and 79-81 years.

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Background: Diets contain toxic chemical contaminants as well as essential nutrients, both of which influence the intrauterine environment for foetal growth. However, whether a high-quality diet that is nutritionally healthy also results in lower exposure to chemical contaminants is unknown.

Objective: We examined associations between periconceptional maternal diet quality and circulating concentrations of heavy metals during pregnancy.

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Background: Both poor maternal nutrition and toxic heavy metal exposure influence foetal growth and development. However, whether consumption of a variety of healthy foods modifies the association between prenatal heavy metal exposure and foetal growth is unknown.

Objective: We examined whether long-term maternal diet quality in periconception modifies the associations between maternal circulating concentrations of heavy metals and foetal growth.

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Milk is a good source of fats, minerals, and vitamins. The present prebirth cohort study examined the association between maternal dairy product intake during pregnancy and the risk of childhood behavioral problems in 5-year-old Japanese children. Study subjects were 1199 mother-child pairs.

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Objective: Tryptophan is an essential amino acid wholly derived from diet. While the majority of tryptophan is degraded through the kynurenine pathway into neuroactive metabolites like quinolinic acid and kynurenic acid, a small proportion of ingested tryptophan is metabolized into the neurotransmitter serotonin. The current cross-sectional study in Japan examined the association between tryptophan intake and depressive symptoms during pregnancy.

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Purpose: Evidence regarding the relationship between maternal calcium intake during pregnancy and childhood blood pressure is limited and inconsistent. The present prebirth cohort study examined this issue in Japanese children aged 6 years.

Methods: Subjects were 854 mother-child pairs.

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A future sustainable dietary pattern for Japanese is yet undefined. This study aimed to explore more sustainable Japanese diets that are nutritious, affordable and with low greenhouse gas emissions (GHGE) and particular emphasis on cultural acceptability. A newly developed data envelopment analysis (DEA) diet model was applied to 4-d dietary record data among 184 healthy Japanese men and 185 women volunteers aged 21-69 years.

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It is uncertain whether the effects of prenatal exposure to isoflavones on childhood behaviour are beneficial or detrimental. This prebirth cohort study investigated the associations between maternal consumption of soy products and isoflavones during pregnancy and behavioural problems in Japanese children aged 5 years. Subjects were 1199 mother-child pairs.

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Objectives: Lower maternal metal intake during pregnancy might affect childhood development. The current prebirth cohort study investigated the relationship between maternal intake of zinc, magnesium, iron, copper, and manganese during pregnancy and behavioral problems in Japanese children aged five years.

Methods: Subjects were 1199 mother-child pairs.

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Aim: To examine the association between maternal caffeine intake during pregnancy and the development of food allergy in young Japanese children up to 3 years of age.

Methods: The study involved 1522 mother-child pairs. Data on maternal caffeine intake during pregnancy were assessed with a validated diet history questionnaire.

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Recently, more attention has been paid to behavioral problems in children. However, for the most part, risk factors for these problems have yet to be determined. The current prebirth cohort study investigated the relationship between maternal calcium consumption during pregnancy and behavioral problems in five-year-old Japanese children.

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Objective: The aim of this pre-birth cohort study was to examine the associations between maternal intake of vegetables, fruit, and antioxidants during pregnancy and behavioral problems in Japanese children 5 y of age.

Methods: Participants were 1199 mother-child pairs. Dietary intake was assessed using a diet history questionnaire.

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Background: The National Nutrition Survey on Preschool Children, Japan (NNSPC) provides fundamental information for policy making for child nutrition. However, the response rate and background characteristics of subjects are unclear. Here, we examined response rate and sociodemographic factors related with response to the survey and evaluated the magnitude of bias due to selective response in the survey estimates of the NNSPC.

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There is growing recognition that eating slowly is associated with a lower risk of obesity, and chewing well might be an effective way to reduce the eating rate. However, little is known about these relationships among children. We therefore investigated the associations of eating rate and chewing degree with weight status among 4451 Japanese children aged 5⁻6 years.

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The current prebirth cohort study investigated the relationship between maternal B vitamin intake during pregnancy and behavioral problems in Japanese children aged 5 years. Subjects were 1199 mother-child pairs. Dietary intake was assessed using a diet history questionnaire.

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Purpose: Oral stereognostic ability (OSA) is a useful indicator of oral perception to recognize food characteristics during mastication. Previous studies have shown associations between dietary intake and oral health status, such as taste perception. However, the effect of oral sensory ability on dietary intake is unclear.

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Purpose: The purpose of this study was to examine whether preconception maternal dietary pattern is associated with in vitro fertilization (IVF) outcome among Japanese women.

Methods: This prospective study included 140 Japanese women who underwent conventional-IVF/intracytoplasmic sperm injection. The patients' diets during the previous month before egg retrieval were assessed with validated brief-type self-administered diet history questionnaire.

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Background: There is increasing evidence of causal links between poor mastication and cognitive impairment, but possible effects of dietary hardness, which clearly affects mastication, on cognitive function are unknown.

Objective: We investigated the hypothesis that hardness of the habitual diet would be associated with cognitive function among older Japanese adults.

Methods: The subjects of this cross-sectional study were 635 Japanese community-dwelling people aged 69-71 years.

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We assessed the adequacy of nutrient intakes of Japanese children aged 3⁻5 years. Dietary information was collected using a 3-nonconsective-day weighed dietary record among 143 boys and 143 girls. Estimates of usual nutrient intakes from foods and beverages were obtained using the best-power method.

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