Publications by authors named "Hitomi Ohtake"
Background: Muscle wasting during cancer cachexia contributes to patient morbidity. Cachexia-induced muscle damage may be understood by comparing its symptoms with those of other skeletal muscle diseases, but currently available data are limited.
Methods: We modelled cancer cachexia in mice bearing Lewis lung carcinoma/colon adenocarcinoma and compared the associated muscle damage with that in a murine muscular dystrophy model (mdx mice).
Article Synopsis
- - The study investigates the role of the TRPV2 channel in dilated cardiomyopathy (DCM), a heart condition characterized by enlarged ventricles and poor contraction, suggesting that abnormal calcium (Ca(2+)) handling worsens this disease.
- - Researchers found that TRPV2 is significantly activated in DCM patients and animal models, and that blocking TRPV2 could reduce harmful calcium influx and protein activities that contribute to heart damage and fibrosis.
- - Inhibiting TRPV2, either through genetic manipulation or with drugs like tranilast, showed potential in alleviating DCM symptoms, preventing heart dilation, and improving the survival rates of test animals, indicating a new approach for treating advanced heart failure.