Publications by authors named "Hisayo Matsuyama"
Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin.
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- This study examined potential biomarkers that indicate pulmonary disease status in sarcoidosis patients, as no effective markers currently exist.
- Researchers analyzed plasma levels of matrix metalloproteinase 7 (MMP-7), CC-chemokine ligand 18 (CCL-18), and periostin in 60 sarcoidosis patients and found significantly higher concentrations compared to 30 healthy controls.
- MMP-7 was identified as the most reliable biomarker for assessing pulmonary lesions in sarcoidosis, showing a negative correlation with pulmonary function and suggesting its potential for diagnosis and disease evaluation.
Although the pathogenesis of sarcoidosis is not fully understood, immunological characterization has elucidated highly polarized expression of the type 1 T helper cell response. Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize bacterial riboflavin and rapidly produce cytokines such as interferon γ and tumor necrosis factor α. We prospectively evaluated the proportion of MAIT cells and the expression levels of cell surface markers in peripheral blood from 40 sarcoidosis patients and 28 healthy controls.
View Article and Find Full Text PDFAlthough numerous recent studies have reported the development of sarcoidosis in patients treated with tumor necrosis factor alpha (TNF-α) inhibitors, it is unclear whether the pathogenesis of drug-induced sarcoidosis is identical to that of spontaneous sarcoidosis. We herein present the case of a patient who developed sarcoidosis 6 months after the introduction of etanercept as treatment for rheumatoid arthritis. Typical clinical symptoms with noncaseating epithelioid granulomas detected in a mediastinal lymph node specimen were consistent with the diagnosis of sarcoidosis.
View Article and Find Full Text PDFInvasive pulmonary aspergillosis (IPA) usually occurs in patients with severe immunodeficiencies involving neutropenia. Underlying lung disease is a well-known risk factor of IPA; however, interstitial lung disease has not been recognized as a risk factor of IPA. We herein report a patient with fibrotic nonspecific interstitial pneumonia who experienced IPA without neutropenia.
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- Corynebacterium ulcerans has been identified as a zoonotic infection, suggesting it can be transmitted from animals to humans.
- The report describes two cases of severe pneumonia in patients where the infection led to the formation of a harmful pseudomembrane in the bronchus due to the diphtheria toxin produced by C. ulcerans.
- The study aims to raise awareness among healthcare providers about the potential severity and risks associated with Corynebacterium species beyond the commonly known C. diphtheriae.