Publications by authors named "Hisayo Asami"
Article Synopsis
- The study investigates the role of ARHGAP24 in the process of pseudopod formation in breast carcinoma cells, focusing on its relationship with activated ARF6.
- Researchers used MDA-MB-231 breast carcinoma cells to show that knocking down ARHGAP24 leads to longer-lasting pseudopods and greater pseudopod length when ARF6 is activated.
- The findings suggest that ARHGAP24 is important for regulating actin remodeling and pseudopod dynamics in cancer cells influenced by ARF6.
The small GTP-binding protein Arf6 reorganizes the actin cytoskeleton through the regulation of Rac activity. We identified FilGAP, a Rac-specific Rho GTPase-activating protein that is recruited to plasma membranes by binding to activated Arf6. FilGAP binds to Arf6 through its pleckstrin homology domain.
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