Publications by authors named "Hisashi Nagamoto"
Background: Loop diuretics are used to manage fluid retention in patients with end-stage kidney disease undergoing hemodialysis (HD). This randomized, double-blind, placebo-controlled, Phase 2 trial evaluated the efficacy and safety of tolvaptan, a vasopressin V2 receptor antagonist, in Japanese HD patients.
Methods: A total of 124 patients (24-h urine volume ≥500 mL) on thrice-weekly HD were randomized to receive oral tolvaptan 15 mg/day (n = 40), tolvaptan 30 mg/day (n = 40) or placebo (n = 44) for 24 weeks.
Article Synopsis
- - The study investigated how different assessments of oral mucositis severity from chemoradiotherapy can impact cancer treatment outcomes, emphasizing the need for effective therapies to manage this side effect.
- - Researchers compared the severity grades of oral mucositis evaluated by local investigators and an independent central review, finding a significant discrepancy of 34% between the two assessments.
- - The results showed differences in the rates of severe mucositis among treatment groups, indicating that using a standardized and objective evaluation method is crucial for improving clinical trial accuracy and treatment effectiveness.
Tetomilast was originally identified as a potent inhibitor of superoxide production in human neutrophils, and is of interest because it may relieve oxidative stress related to chronic obstructive pulmonary disease (COPD). Our objective was to determine whether tetomilast effectively protects against the development of porcine pancreatic elastase (PPE)-induced emphysema in rabbits. Rabbits were divided into three groups (sham n=19, PPE n=19, PPE/Tetomilast n=18).
View Article and Find Full Text PDFBackground: Tetomilast (OPC-6535) was originally developed as a compound inhibiting superoxide production in neutrophils. Although its mechanism of action is not completely understood, phosphodiesterase type 4 inhibitory function has been postulated. The therapeutic effect of PDE4 inhibitors has been reported for chronic inflammatory disorders such as chronic obstructive pulmonary diseases.
View Article and Find Full Text PDFWe investigated therapeutic efficacy of rebamipide using dextran sulfate sodium (DSS) induced colitis model in rats. Three percent DSS solution was given to rats for 9 days. After that, we evaluated the drug efficacy on colitis sustained with continuous drinking of 1% DSS.
View Article and Find Full Text PDFBackground: The objective of this study was to investigate the effects of OPC-6535 on Propionibacterium acnes-primed and lipopolysaccharide-induced liver injury in the rat.
Methods: P. acnes was administered intravenously to the rat at 16 mg/kg 7 days before the experiments.