Publications by authors named "Hisanori Maeoka"
Article Synopsis
- * RAD52, an SSA factor, is more often pulled to repair DSBs at centromeres compared to RAD51 (HR) and DNA ligase IV (NHEJ), suggesting that SSA is key in repairing these breaks, especially at inactive centromeres.
- * Depleting LIG4 or RAD51 increases cell death after DSBs occur at centromeres, while reducing RAD52 prevents this
Background/aim: In a previous study, we have demonstrated heightened Pyra-Metho-Carnil (PMC) efficacy in nude mice with intact innate immunity that lack T and B cells. This has prompted hypothesizing that PMC may target macrophages that promote cancer growth. In this study, we conducted co-culture experiments with macrophages derived from THP-1 human monocyte cell lines and spheroids representing normal and cancer microenvironments.
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