Publications by authors named "Hisako Matsumura"
Article Synopsis
- A preliminary study assessed the safety and feasibility of using erythropoietin (Epo), magnesium sulfate, and hypothermia together to treat neonates with hypoxic-ischemic encephalopathy (HIE).
- Nine neonates received the combination therapy shortly after birth, with no serious adverse events or complications recorded during hospital care.
- By 18 months, while most patients completed their therapy successfully, three exhibited severe neurodevelopmental disabilities, indicating mixed long-term outcomes.
Article Synopsis
- Chorioamnionitis (CAM) increases the risk of bronchopulmonary dysplasia (BPD) in premature infants, highlighting its significance in infant health.
- The study measured levels of interleukin 6 (IL-6), Krebs von den Lungen 6 (KL-6), and transforming growth factor β (TGF-β) in the amniotic fluid to assess inflammation and lung damage.
- Results indicated that higher levels of these markers were linked to more severe CAM and a greater likelihood of developing BPD in affected infants.
Early Hum Dev
September 2016
Article Synopsis
- The study aimed to determine if aggressive nutrition improves growth and neurodevelopment in extremely low birth weight infants born appropriate for gestational age.
- 137 infants were divided into two groups: one received standard nutrition and the other aggressive nutrition, with a focus on amino acid intake starting immediately after birth.
- Results showed that infants in the aggressive nutrition group had better head circumference and cognitive-adaptive scores by age three compared to those in the standard group, indicating potential benefits of aggressive nutrition for neurodevelopment, which should be validated in larger trials.
Pediatr Int
November 2016
Article Synopsis
- The study aimed to explore how glucocorticoids, erythropoietin (EPO), and spironolactone affect lung cells from extremely premature infants with chronic lung disease (CLD).
- Researchers treated human lung fibroblasts and epithelial cells with varying concentrations of these substances along with tracheal aspirate fluid (TAF) taken from affected infants.
- Results showed that certain doses of glucocorticoids and EPO inhibited fibroblast growth but encouraged epithelial cell proliferation, suggesting potential therapeutic uses in managing CLD in premature infants.
