Publications by authors named "Hisako Hashimoto"
Effective activation of small molecules (alcohol, phenol, ketones, amine, .) by a hydrogen-bridged bis(silylene) complex, which has two adjacent Lewis acidic centers and a hydridic bridging hydrogen with weak Si⋯H bonds, is described, along with product characterization by NMR and X-ray diffraction studies.
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- - This study investigates the effectiveness of the minute ventilation-carbon dioxide production slope compared to the oxygen uptake efficiency slope in assessing exercise efficiency in COPD patients.
- - The researchers analyzed data from 122 COPD patients across all GOLD stages, finding significant differences in exercise parameters between mild (GOLD I-II) and more severe (GOLD III-IV) groups.
- - Results showed that the minute ventilation-carbon dioxide production slope had a stronger correlation with key indicators of oxygen consumption than the oxygen uptake efficiency slope, particularly in severe cases of COPD with exertional hypoxemia.
Article Synopsis
- * The study compared clinical data from 29 NTM-PD patients and 12 control participants, finding that NTM-PD patients had lower peak oxygen uptake and correlated changes in oxygen consumption during exercise with ventilatory variables, imaging findings, and cardiac pressure gradients.
- * Results indicate that exertional oxygen consumption is linked to exercise tolerance and ventilatory efficiency in NTM-PD patients, highlighting the importance of tailoring rehabilitation programs to address their unique respiratory challenges like tachypnea and bronchiectasis.
Article Synopsis
- The first successful isolation and characterization of transition metal complexes featuring the Al(I)-H unit were carried out, resulting in W and Fe complexes with yields of 43-63%.
- The synthesis was achieved through a one-step reaction involving specific precursors and was characterized using various techniques, including NMR and IR spectroscopy, as well as DFT calculations.
- Additionally, the strong σ-donating property of the :AlH(NHC) ligand and the positively polarized coordination bonds were confirmed, alongside the validation of the Aluminum's monovalent oxidation state through X-ray photoelectron spectroscopy.
Article Synopsis
- Researchers created new iron complexes using unique ligands that improve catalytic reactions.
- These complexes efficiently catalyzed the double hydroboration of nitriles, yielding bis(boryl)amine with impressive product yields of 85%-95%.
- An equivalent ruthenium complex was less effective, and the study suggests a proposed mechanism involving Fe(0)-silylimine species as potential intermediates in the reaction process.
Article Synopsis
- Researchers previously found that widening the larynx can enhance exercise tolerance in patients with COPD.
- A case study of a severe COPD patient revealed that leaning forward caused extended expiration time and significant laryngeal narrowing while not obstructing the trachea.
- The findings suggest that how body positioning affects airway function could play a crucial role in improving exercise tolerance for individuals with COPD.
Article Synopsis
- * The polarity of the strong Cr(δ-)-Si(δ+) bond was confirmed through reactions with methanol and density functional theory (DFT) calculations, highlighting the reactivity of the complex.
- * Under 365 nm LED irradiation, the chromium silylyne reacted with hydrogen to reform the precursor silylene complex and also reacted with benzene, leading to the formation of products through C-H bond activation and new Si
Article Synopsis
- * A similar η-allyl complex 3 with a germacyclopentenyl ring was produced when complex 1 reacted with butadiene under light, resulting in the cleavage of the Cr≡Ge bond.
- * In contrast, reactions of complex 1 with alkynes, also under light, led to a substitution of a CO ligand, producing η-alkyne germylyne complexes while preserving the Cr≡Ge triple bond.
Article Synopsis
- - A neutral silylyne complex of molybdenum was created using a stepwise dehydrogenation method, and its characteristics were compared to a similar tungsten complex, noting a preference for the monomer form in molybdenum solutions.
- - The molybdenum complex exhibited faster reactivity in [2+2] cycloaddition reactions with alkynes compared to its tungsten counterpart.
- - The study also demonstrated the formation of silaiminoacyl complexes from reactions with organic azides through [2+3] cycloaddition, with structural and bonding analyses supported by various measurements and DFT calculations.
Article Synopsis
- The study investigates expiratory pressure load training (EPT) as a method to improve exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) by targeting laryngeal narrowing.
- In a trial involving 47 COPD patients, those undergoing EPT showed significant improvements in endurance time and peak oxygen uptake compared to control groups.
- The findings suggest that EPT enhances aerobic capacity, increases laryngeal widening, and improves ventilation, even in advanced stages of COPD.
Article Synopsis
- Unsaturated 16-electron iridium and rhodium complexes with a silyl-bipyridine-based SiNN-pincer ligand were successfully synthesized and studied using X-ray crystallography and NMR spectroscopy.
- The iridium-Bpy complex was effective in catalyzing the borylation of C(sp)-H bonds in arenes, producing arylboronate esters with high yields of at least 93%.
- This reaction was carried out under mild conditions, specifically around 40 °C, making it a potentially efficient method for organic synthesis.
Article Synopsis
- - The study investigates the effects of pulmonary rehabilitation (PR) on oxygen uptake and its relation to ventilatory efficiency in patients with severe COPD.
- - Out of 38 patients, 14 showed increased peak oxygen uptake after PR, with notable correlations found between changes in oxygen concentration difference and peak performance indicators.
- - The findings suggest that improved oxygen extraction after PR enhances exercise tolerance and efficiency, highlighting a potential strategy for patients with limited ventilatory ability.
Article Synopsis
- The text indicates there is a correction to an article that can be found under the DOI: 10.3389/fphys.2021.703977.
- It suggests that the original article may have contained errors or inaccuracies that need to be addressed.
- Readers should refer to the corrected version for reliable information and conclusions related to that study.
In contrast to cardiovascular disease, low rather than high ventilatory inefficiency, evaluated by the minute ventilation-carbon dioxide output (-)-slope, has been recognized as being related to greater disease severity in chronic obstructive pulmonary disease (COPD). To better care for patients with cardiopulmonary disease, understanding the physiological correlation between ventilatory inefficiency and exercise limitation is necessary, but remains inadequate. Given that oxygen uptake () evaluated by cardiopulmonary exercise testing (CPET) depends on both the ventilatory capability and oxygen extraction, i.
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- A study analyzed the effects of high-dose cytarabine (HD-AraC) on acute myeloid leukemia (AML) patients before they received allogeneic stem cell transplants.
- Results showed that patients treated with HD-AraC had better outcomes in disease-free survival (DFS), overall survival (OS), and lower relapse rates compared to those who did not receive it.
- Specifically, patients treated with HD-AraC showed 4-year DFS of 79% versus 49%, OS of 82% versus 56%, and a cumulative incidence of relapse of 18% versus 42%.
Article Synopsis
- - A tungsten silylyne complex reacted with aldehydes to form four-membered metallacycles through a [2+2] cycloaddition at room temperature.
- - Heating these metallacycles to 70°C caused them to break apart and form carbyne complexes and silanoic esters, similar to reactions seen in alkyne metathesis.
- - The silanoic ester could further react with pivalaldehyde, resulting in another high-yield cycloaddition product.
Article Synopsis
- * Patients were categorized into groups based on chromosomal abnormalities, revealing that those with the t(11;14) abnormality have a median overall survival (OS) of 64.1 months, significantly better than those with the del 17p abnormality (23.0 months).
- * G-banding analysis showed that t(11;14) patients with additional chromosomal abnormalities had a shorter median OS (46.2 months) compared to those without additional abnormalities and the t(4;
Article Synopsis
- A study analyzed outcomes of 713 patients who developed subsequent solid cancers after hematopoietic cell transplantation (HCT), revealing they were diagnosed at a median age of 55, which is significantly younger than the general population's average age of 67 for primary cancers.
- The survival rate three years post-diagnosis of subsequent solid cancers was 60%, with the overall risk of mortality higher among HCT patients, as these cancers accounted for 76% of deaths in the study cohort.
- Findings highlight the necessity for earlier cancer screening in HCT patients, as they generally face worse survival outcomes compared to the general population for certain cancers, while the biological and genetic factors are still unclear.*
[Mitoxantrone, etoposide, and cytarabine combination therapy for acute myeloid leukemia patients failing to achieve a complete remission after induction chemotherapy: a single-center experience].
Mari Morita-Fujita Tomohiro Yabushita Yoshimitsu Shimomura Yuichiro Ono Nobuhiro Hiramoto Hisako Hashimoto
Rinsho Ketsueki
July 2019
Article Synopsis
- This retrospective study evaluates the safety and efficacy of the MEC (mitoxantrone, etoposide, cytarabine) chemotherapy regimen for patients with acute myeloid leukemia (AML) who did not achieve complete remission (CR) after initial treatment.
- The study involved 24 patients with a median age of 58, and 45.8% of them achieved CR after one course of the MEC regimen, demonstrating a good response rate.
- While all patients experienced febrile neutropenia and some had acute infections, the MEC regimen was found to have acceptable side effects, with no therapy-related deaths, making it a viable salvage treatment option.
Article Synopsis
- The article initially had an error in figure 1a, incorrectly labeling "Autologous HCT(n=111)".
- The correct label should be "Allogeneic HCT (n=51)".
- The updated figure with the correct information is provided below.
Article Synopsis
- Vancomycin is an important antibiotic for patients receiving allogeneic hematopoietic stem-cell transplantation (allo-HSCT), but its effectiveness can vary significantly based on individual factors like kidney function.
- A study developed a population pharmacokinetic (PopPK) model for vancomycin specifically for allo-HSCT patients, analyzing data from 95 patients and 285 observations to optimize dosing.
- The findings revealed altered pharmacokinetics in these patients compared to the general population, leading to the creation of a dosing nomogram that helps in making evidence-based adjustments to vancomycin therapy.
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- Rituximab improves outcomes for B-cell lymphoma patients, but relapsed or refractory mantle cell lymphoma (MCL) remains challenging due to poor prognosis.
- A study analyzed 162 R/R MCL patients who underwent either autologous or allogeneic hematopoietic cell transplantation (HCT) from 2004 to 2014, showing median overall survival of 48 months for autologous HCT and 65 months for allogeneic HCT.
- Risk factors for overall survival included older age, higher comorbidity scores, and specific treatment regimens for autologous HCT, while better performance status and longer diagnosis-to-treatment intervals were important for allogeneic HCT, suggesting a need