Publications by authors named "Hisahiro Uemura"
Background: Recent evidence suggests that the presence of microbiome within human pancreatic ductal adenocarcinoma (PDAC) tissue potentially influences cancer progression and prognosis. However, the significance of tumor-resident microbiome remains unclear. We aimed to elucidate the impact of intratumoral bacteria on the pathophysiology and prognosis of human PDAC.
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- Aging is linked to a higher occurrence of pancreatic cysts and intraductal papillary mucinous neoplasms (IPMNs), with metabolic syndrome potentially increasing this risk.
- * A study involving 9,363 patients found that 198 had pancreatic cysts, among which 129 were diagnosed with IPMNs, showing a strong correlation between IPMN presence and increasing age.
- * Factors like high body mass index, smoking history, and metabolic syndrome were associated with a greater prevalence of IPMN, especially in elderly patients with metabolic syndrome.
Pancreatic cancer primarily arises from microscopic precancerous lesions, such as pancreatic intraepithelial neoplasia (PanIN) and acinar-to-ductal metaplasia (ADM). However, no established method exists for predicting pancreatic precancerous conditions. Endoscopic ultrasonography (EUS) can detect changes in pancreatic parenchymal histology, including fibrosis.
View Article and Find Full Text PDFBackground: Abundant collagen deposition is a hallmark of pancreatic ductal adenocarcinomas (PDACs). This study clarified the interactive relationship between tumor-stromal collagen, molecular and immune characteristics, and tumor pr ogression in human PDAC.
Methods: We performed a comprehensive examination using an integrative molecular pathological epidemiology database on 169 cases with resected PDAC .
Background: Sarcopenia, defined as a loss of skeletal muscle mass and quality, is found in 30-65% of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis, and is a poor prognostic factor. However, it is yet to be evaluated why sarcopenia is associated with poor prognosis. Therefore, this study elucidated the tumor characteristics of PDAC with sarcopenia, including driver gene alterations and tumor microenvironment.
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- A case study highlights a 35-year-old man with recurrent pancreatitis, linked to a specific genetic mutation (IVS3+2T>C) in the serine protease inhibitor Kazal type 1 gene.
- Despite initially mild symptoms and conservative treatment, his condition escalated to chronic pancreatitis with complications like pancreatic calcification and duct stenosis within three years.
- The case stresses the necessity of genetic testing in unexplained pancreatitis cases to identify underlying causes and track disease progression.
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- Tertiary lymphoid structures (TLS) in pancreatic ductal adenocarcinoma (PDAC) are linked to a strong immune response and better patient survival rates.
- A study involving 162 PDAC cases showed that TLS presence correlates with increased levels of various tumor-infiltrating lymphocytes (TILs), particularly CD4 and CD8 T cells.
- The findings suggest that TLS serve as a marker for robust anti-tumor activity and could help predict patient outcomes and responses to treatment, despite not being linked to specific genetic alterations.
Background And Aim: Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding and lobularity, may be associated with the severity of chronic pancreatitis (CP). However, the correlation between parenchymal EUS findings and histology remains unclear. We designed a large-scale retrospective study analyzing over 200 surgical specimens to elucidate the association between parenchymal EUS findings and histological features.
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- * Conducted on 81 patients from January 2008 to May 2020, researchers found that 30.9% required a step-up treatment, with several clinical indicators identified, including the number of PFC-occupied regions and the remaining percentage of PFC post-drainage.
- * The conclusion suggests that specific pre- and post-treatment characteristics can help identify patients who will benefit from a step-up approach, while those without these indicators may not need further intensive treatment.
Endoscopic papillectomy for early ampullary tumors is considered a minimally invasive and useful alternative to pancreatoduodenectomy; however, its indications remain unclear. This study aimed to clarify the advantages of endoscopic papillectomy by investigating the clinical outcomes of patients who underwent endoscopic papillectomy or pancreatoduodenectomy for early ampullary tumors. Patients diagnosed with early ampullary tumors (adenoma, Tis, T1a) who underwent endoscopic papillectomy or pancreatoduodenectomy between June 2008 and October 2019 were included, and their clinical outcomes were analyzed.
View Article and Find Full Text PDFBackground: Pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN) is defined as PDAC occurring apart from IPMN. This study comprehensively investigated the molecular biologic characteristics of PDAC concomitant with IPMN in major genetic alterations, tumor microenvironment, and prognosis by contrast with those of conventional PDAC.
Methods: The study retrospectively reviewed the data of 158 surgically resected PDAC patients.
Background: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is associated with acute pancreatitis (AP) in some cases, however its causes have not been fully elucidated. We investigated the association of the incidence of AP with epithelial subtypes and pancreatic volume in IPMN.
Methods: This retrospective study included 182 consecutive surgically resected IPMN patients between January 2000 and December 2018.
Endoscopic submucosal dissection (ESD) for gastric neoplasms is a useful treatment globally. However, postoperative bleeding after gastric ESD is a serious, and sometimes life-threatening complication in patients receiving antithrombotic drugs, because antithrombotic drugs are considered to increase the risk of postoperative bleeding after gastric ESD. In contrast, withdrawal of antithrombotic drugs during the perioperative period increases the risk of thrombotic complications.
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