Synthesis, Structure, and Spectroscopic Properties of [Fe (tnpa)(OH)(PhCOO)]ClO : A Model Complex for an Active Form of Soybean Lipoxygenase-1.

The cis configuration between the hydroxo and the carboxylato and the three amino groups of the tetradentate, tripodal ligand tris(6-neopentylamino-2-pyridylmethyl)amine favors the formation of hydrogen bonds which stabilize the hydroxo-Fe complex 1. Thus, its structure closely resembles that of the active center of Fe -soybean lipoxygenase-1, which also contains a six-coordinate Fe atom.

Structural and Spectroscopic Characterization of a Mononuclear Hydroperoxo-Copper(II) Complex with Tripodal Pyridylamine Ligands.

A model for the key intermediate in copper oxygenase reactions, the Cu(II)-OOH complex, was prepared with the novel tripodal pyridylamine ligand, bis(6-pivalamide-2-pyridylmethyl)(2-pyridylmethyl)amine. The HOO moiety is stabilized by hydrogen bonding to two amine H atoms (see structure on the right).