Publications by authors named "Hiroyo Kubota"
Article Synopsis
- BCAA (branched-chain amino acids) may help slow the progression of chronic liver disease, particularly in the early stages, but their benefits in this context have been uncertain.
- A study involving rats showed that those given BCAA supplements had a delayed increase in liver damage markers and less liver fibrosis compared to those who did not receive BCAA.
- BCAA supplementation reduced liver cell death (apoptosis) and altered specific protein levels involved in cell survival, suggesting a protective effect against liver disease progression.
We examined whether continuous supplementation with branched-chain amino acids phosphorylates ribosomal protein S6, a downstream effector of mammalian target of rapamycin, and improves hypoalbuminemia of rats with chronic liver disease. Sprague-Dawley rats were fed a casein diet (control group) or a branched-chain amino acid-supplemented casein diet (branched-chain amino acid group) for 11 weeks with repeated injections of carbon tetrachloride. Throughout this experimental period, no significant difference in plasma albumin concentration was seen between groups.
View Article and Find Full Text PDFDietary medium-chain triglycerides attenuate hepatic lipid deposition in growing rats with protein malnutrition.
J Nutr Sci Vitaminol (Tokyo)
December 2011
The objective of this study was to investigate the effects of dietary medium-chain triglycerides (MCT) on hepatic lipid accumulation in growing rats with protein malnutrition. Weaning rats were fed either a low-protein diet (3%, LP) or control protein diet (20%, CP), in combination with or without MCT. The four groups were as follows: CP-MCT, CP+MCT, LP-MCT, and LP+MCT.
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