The Effect of Bone Marrow Mesenchymal Stem Cells on Nestin and Gene Expression and Spatial Learning (Percent Alternation Y-Maze Test) against AlCl-Induced Alzheimer's-like Pathology in a Rat Model.

Background: Alzheimer's disease (AD) is a neurodegenerative condition characterized by gradual cognitive impairment, including loss of synapses and nerve cells involved in learning, memory, and habit formation processes. Bone Marrow Mesenchymal Stem Cells (BM-MSCs) are multipotent cells. Because of their self-renewable, differentiation, and immunomodulatory capabilities, they are commonly used to treat many disorders.

Effect of remote ischemic postconditioning on left ventricular ejection fraction in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

Background: Ischemic conditioning may help patients with ST-segment elevation myocardial infarction (STEMI) to limit ventricular remodeling.

Objectives: To investigate the effect of remote ischemic postconditioning (RIPC) on left ventricular function during primary percutaneous coronary intervention (PPCI) in patients with STEMI.

Material And Methods: Pre- and post-test intervention study with a total of 60 STEMI patients.

Non-monotonic dose-response of di-(2-ethylhexyl) phthalate isolated from XT6 on adipogenesis and expression of and in 3T3-L1 adipocytes.

Objectives: Adipogenesis is the fat cell formation process regulated by peroxisome proliferator-activated receptors (). The insulin-responsive glucose transporter 4 () has a major role in glucose uptake and metabolism in insulin target tissues (i.e.

The gene is involved in Wharton's jelly derived mesenchymal stem cell treatment of Alzheimer's disease in rats.

Introduction: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer's disease (AD).

Methods: Twenty male adult Wistar rats were randomly distributed into three groups of animals ( = 5). The AlCl group was given 300 mg/kg body weight (BW) of AlCl intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed.

The Role of High Sensitivity C-reactive Protein to Predict Delirium Persistence in Elderly Patients with Pneumonia: A Prospective Cohort Study.

Background: Delirium is a disorder of acute full attention, and cognitive function commonly occurs at elderly which  can prolong hospitalization, dependence rate, morbidity, and mortality, with pneumonia infection as one of its risk factors. Several markers have been studied for delirium, but relationship between delirium severity and persistence remains unclear. This study aimed to examine the role of hs-CRP, pNF-H, S100B, and NLR to predict delirium persistence.

alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model.

Objectives: Gestational diabetes (GDM) complications affect maternal and fetus . GDM's vascular dysfunction showed inducible nitric oxide synthase (iNOS) alteration and was linked to the higher production of nitrogen species, leading to diabetic embryopathy. () has been reported for its anti-inflammatory and anti-diabetic effects.

SCUBE2, vascular endothelium, and vascular complications: A systematic review.

The vascular endothelium plays a vital role in regulating normal vascular function. Endothelial lining maintains the balance of thrombolytic and fibrinolytic microenvironment in the vasculature. Alterations of vascular endothelium referred to as endothelial dysfunction, caused the pathological changes in vessel wall such activation of proinflammatory and procoagulatory that initiate atherosclerosis.

Upregulation of SCUBE2 expression in dyslipidemic type 2 diabetes mellitus is associated with endothelin-1.

Type 2 diabetes mellitus (T2DM) is a major health problem for morbidity and mortality world-wide due to diabetic vascular complication. Following T2DM, dyslipidemia is known well for the main reason of vascular complication leading to atherosclerosis and impaired life expectancy in diabetes. Thus, a new prediction marker in T2DM could help prevent the progression disease despite of metabolic control.

Upregulation of SCUBE1 in Dengue Virus Infection.

Background: Dengue is a major communicable disease in tropical areas, with an increasing prevalence every year. Thrombocytopenia is one of the commonly used laboratory parameters for predicting the severity of the disease. It is detected on day 6 or day 7 after the febrile stage, and its presence indicates that the disease has become potentially fatal.

Localization and characterization of a novel secreted protein, SCUBE2, in the development and progression of atherosclerosis.

Inhibition of atherosclerosis progression has long been the subject of intensive pathophysiologic investigations. The identification of a novel target molecule to redeem the cellular processes remains a major challenge in cardiology. Signal peptide CUB domain EGF-like repeat protein (SCUBE) family has been detected on human tissues and cultured cells.