Publications by authors named "Hiroto Maru"
Yakugaku Zasshi
February 2011
Article Synopsis
- Sperminated pullulans (SP) of varying molecular weights were studied for their ability to enhance insulin absorption in rats, showing positive effects when combined with insulin.
- In vivo tests indicated low toxicity, while in vitro experiments revealed tighter junctions were affected, but toxicity levels were lower at these concentrations.
- A high molecular weight of SP is suggested to be beneficial for developing safe, effective formulations for peptide and protein drugs, with changes in tight junction proteins potentially playing a role in the absorption process.
