Publications by authors named "Hiroto Kakita"

Article Synopsis
  • The study investigated the effect of administering P2Y inhibitors during endovascular treatment (EVT) in patients with anterior circulation thrombosis due to acute ischemic stroke.
  • Out of 242 patients analyzed, those who received P2Y inhibitors had a significantly higher rate of carotid artery stenting and better functional outcomes after 90 days compared to those who did not.
  • The results showed that patients treated with P2Y inhibitors had an adjusted odds ratio of 6.65 for better outcomes, suggesting a strong positive association with the use of these medications.
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Background And Purpose: Reocclusion after treatment is a concern in endovascular therapy for isolated intracranial atherothrombotic stroke-related large-vessel occlusion (AT-LVO). However, the optimal endovascular therapy technique for AT-LVO has not yet been investigated. This study evaluated the optimal endovascular therapy technique for AT-LVO in a real-world setting.

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Article Synopsis
  • Enteral nutrition is crucial for stroke patients who struggle with eating, but traditional feeding methods are time-consuming and can disrupt care.
  • The Rapid EN trial aims to compare the safety of quickly administering enteral nutrition (100 mL in 5 minutes) versus the conventional method (100 mL in 30 minutes) in acute stroke patients.
  • The study will track complications like vomiting and pneumonia within 7 days, assessing if the faster method is equally safe while also looking at overall treatment times and clinical outcomes.
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Article Synopsis
  • Atherothrombotic stroke-related large vessel occlusion (AT-LVO) occurs from either intracranial artery occlusion or embolism from cervical carotid issues, with unclear outcomes after endovascular therapy (EVT).
  • A study involving 582 patients revealed that those with intracranial occlusions were generally younger, had a lower smoking rate, and experienced a higher incidence of recurrent ischemic strokes after EVT compared to the tandem group.
  • Although the intracranial group had worse overall outcomes (22.5% recurrence vs. 8.2%), there were no significant differences in rates of intracerebral hemorrhage or death between the two groups.
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Objective: The term "weekend effect" refers to an increase in the mortality rate for hospitalizations occurring on weekends versus weekdays. In this study, we investigated whether such an effect exists in patients undergoing mechanical thrombectomy for acute ischemic stroke with large vessel occlusion (currently the standard treatment for this condition) at a single center in Japan.

Methods: We surveyed 151 patients who underwent mechanical thrombectomy for acute ischemic stroke with large vessel occlusion (75 and 76 patients were treated during daytime and nighttime, respectively) from January 2019 to June 2021.

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Objective: We describe the rare case of a patient who was treated for a ruptured distal posterior inferior cerebellar artery (PICA) aneurysm via an ipsilateral persistent primitive proatlantal artery (PPPA).

Case Presentation: An 86-year-old female with a medical history of hypertension presented with headache and nausea. CT showed subarachnoid hemorrhage in the posterior cranial fossa, and CTA revealed an aneurysm at the left-side distal PICA.

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Objective: Acute mechanical thrombectomy (AMT) in patients with acute ischemic stroke from large vessel occlusion (LVO) is performed without directly identifying the occluded vessels. In this study, we evaluated whether 1.5 T magnetic resonance imaging (MRI) with 3D-fast imaging employing steady-state acquisition (FIESTA) could visualize the occluded intracranial middle cerebral artery (MCA) and internal carotid artery (ICA) before AMT.

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Mechanical thrombectomy has become a standard treatment for acute ischemic stroke with large vessel occlusion. In aged patients, it is difficult to guide the catheter via the transfemoral approach due to vessel tortuosity and aortic elongation. We report our preliminary clinical experience using the transbrachial approach.

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Background: Traumatic intracranial aneurysms are rare complications after head trauma. This report describes the case of a patient with a traumatic pericallosal aneurysm.

Case Description: A 73-year-old man developed headache and lower limb paresis, and emergency computed tomography scan revealed a hematoma in the corpus callosum.

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Objective: There are regional disparities in endovascular thrombectomy, and problems with emergency transport systems and hospital collaboration when transferring need to be addressed. In this study, the clinical outcomes of endovascular thrombectomy for transferred patients were analyzed.

Methods: Acute ischemic stroke patients who underwent endovascular thrombectomy between January 2016 and March 2019 were enrolled.

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Objective: Multiple randomized trials have demonstrated the efficacy of mechanical thrombectomy (MT), but very elderly patients aged ≥90 years were excluded. It remains uncertain whether endovascular therapy is effective for nonagenarians. The objective of this study was to investigate the effectiveness and safety of MT in nonagenarians.

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Background And Purpose: Endovascular therapy (EVT) is strongly recommended for acute cerebral large vessel occlusion with the Alberta Stroke Program Early CT Score (ASPECTS) ≥6 due to occlusion of the internal carotid artery or M1 segment of the middle cerebral artery. However, the effect of EVT for patients who have ischemic core with ASPECTS ≤5 (0–5) was not established. The purpose of this study was to elucidate the outcomes of EVT for patients with large ischemic core.

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