Publications by authors named "Hirotaka Tokai"

Aim: The risk of developing hemorrhagic complications during or after surgery in patients receiving antithrombotic therapy remains uncertain. Moreover, the impact of antithrombotic therapy under an acute inflammatory status is unclear. We investigated the impact of antithrombotic therapy in patients undergoing emergency laparoscopic cholecystectomy for acute cholecystitis.

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  • Schistosomiasis is a tropical disease that can lead to chronic health issues, including complications like appendicitis, which is rare but notable in developed countries.
  • A case study detailed a 34-year-old Filipino sailor who experienced acute appendicitis and was found to have schistosome eggs during surgery, despite initial negative tests for adult worms.
  • The findings suggest that healthcare providers should be aware of the possibility of schistosome-related appendicitis, as its incidence may rise in areas like Japan due to increased international travel and migration.
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Aim: The aim was to analyze the correlation between psoas muscle mass and mortality, as well as postoperative complications in patients treated for colonic perforation.

Patients And Methods: A total of 46 patients met the study criteria. Patients were classified into an elderly (age, ≥75 years, n=24) and a younger group (age, <75 years, n=22).

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Background: Primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is extremely rare, and its biological behavior, pathogenesis, optimum treatments, and prognosis remain to be elucidated. We herein report a case of PRMC with an 80-month follow-up.

Case Presentation: A 29-year-old woman was diagnosed with unknown retroperitoneal tumor with benign right ovarian cyst and uterine fibroids, and she underwent laparotomy.

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Gallbladder small cell carcinoma (SCC) comprises only 0.5 % of all gallbladder cancer and consists of aggressive tumors with poor survival outcomes against current treatments. These tumors are most common in elderly females, particularly those with cholecystolithiasis.

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The granulocyte-colony-stimulating factor (G-CSF)-producing esophageal carcinosarcoma is extremely rare in esophageal cancer. In the present case, multidisciplinary therapy, which is surgical resection with preoperative chemotherapy, has been effectively treatment to granulocyte-colony-stimulating factor producing esophageal carcinosarcoma of the esophagus.

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Plasmablastic lymphoma (PBL) is a rare form of non-Hodgkin's lymphoma that is associated with human immunodeficiency virus (HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. This report represents an unusual case of HIV-negative PBL that occurred in the sigmoid colon.

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A 50-year-old male was examined at another hospital for fever, general fatigue and slight abdominal pain. He was treated with antibiotics and observed. However, his symptoms did not lessen, and laboratory tests revealed liver dysfunction, jaundice and an increased inflammatory response.

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Nanoparticle albumin-bound paclitaxel (nab-PTX) is a key drug used in breast cancer treatment which often causes chemotherapy-induced peripheral neuropathy (CIPN). No effective approach for CIPN control has been established to date. This study assessed a new approach to CIPN integrating two concepts: compression therapy using stockings and sleeves, and medication therapy using selected prophylactic drugs, including goshajinkigan, which we named the "3S" approach.

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  • The study investigates how the removal of autonomic hepatic nerves after liver transplantation affects the accumulation of hepatic progenitor cells (HPC) during liver regeneration.
  • Male Sprague-Dawley rats were used, with one group undergoing hepatic denervation and another group receiving a sham operation before a two-thirds hepatectomy.
  • Results showed that while both groups demonstrated increasing HPC levels, the denervated rats had significantly higher HPC numbers from postoperative day 5 through 14, suggesting the autonomic nerves are important in regulating HPC accumulation during liver regeneration.
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  • - The study investigates the potential for hepatocyte transplantation to achieve liver repopulation in a rat model with chemically and surgically induced liver failure, focusing on the combination of proliferative stimuli and suppression of host liver cells.
  • - Testing involved transplanting Dipeptidyl peptidase IV-positive (DPPIV+) hepatocytes into DPPIV-deficient (DPPIV-) recipient rats that underwent carbon tetrachloride treatment and partial hepatectomy, with liver regeneration and repopulation rates assessed.
  • - Results indicated successful liver repopulation in rats subjected to both carbon tetrachloride and partial hepatectomy, with significant increases in DPPIV+ cell counts and proliferation observed from day 7 to
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A 57-year-old man was transferred to our hospital because of gluteal pain. His right buttock had flare and swelling. Complete blood count showed leukocytosis, and renal failure was evident.

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Aim: Recent reports have shown that bone marrow cells (BMC) retain the potential to differentiate into hepatocytes. Thus, the BMC have been recognized as an attractive source for liver regenerative medicine. However, it has not been clarified whether BMC transplantation can be used to treat liver damage in vivo.

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Aim: Hepatocellular carcinoma (HCC) arising from the end stages of liver cirrhosis is a fair indication for liver transplantation (LT). To pathologically investigate the multicentric occurrence of relatively early staged HCC in cirrhosis, we studied whole explanted livers.

Methods: Fourteen explanted livers from patients undergoing living donor LT (LDLT) were examined.

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  • The study aimed to investigate how cyclosporin A (CyA), an immunosuppressive drug, affects metabolism and liver regeneration in rats after a significant surgical removal of the liver (70% hepatectomy).
  • Rats were divided into three groups receiving different doses of CyA, and their liver regeneration and CyA serum levels were analyzed over a period after surgery.
  • Results showed that higher doses of CyA enhanced liver regeneration but also indicated a decrease in the metabolic activity of CyA over time, which could complicate dosing during liver transplantation recovery.
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Case reports of severe idiopathic portal hypertension (IPH) requiring liver transplantation are very rare. We report the case of a 65-year-old woman who was diagnosed as having IPH. At the age of 60 years, her initial symptom was hematemesis, due to ruptured esophageal varices.

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A 54-year-old woman was admitted to our hospital following the diagnosis of decompensated liver cirrhosis with hepatitis C. She underwent living-donor liver transplantation, performed using the left hepatic lobe with the middle hepatic vein donated by her husband. After the transplantation, the patient suffered from massive ascites with liver dysfunction.

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Background/aims: E-cadherin (E-cad) is a type of adhesion molecule, and recent studies have demonstrated a correlation between its expression in tumor lesions and the recurrence of HCC. Serum levels of soluble E-cad are significantly elevated in patients with several types of cancer. The authors evaluated the significance of the serum level of soluble E-cad as a predictor of early recurrences (intrahepatic or extrahepatic metastasis) of HCC after a curative resection.

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Background: Saline-linked electric cautery (SLC) is introduced as an effective device to reduce blood loss in liver surgery. The aim of the current study was to evaluate the safety and efficacy of a 2-surgeon technique using SLC and the Cavitron Ultrasonic Surgical Aspirator (CUSA; Valleylab, Boulder, CO) in living donor hepatectomy.

Methods: Forty-three living donor right hepatectomy cases were enrolled in this study.

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Background: Recently we reported that signal transmission of interferon is more suppressed by tacrolimus (Tac) than cycrosporine (CyA). Therefore, although CyA might be beneficial immunosuppressive drug after liver transplantation (LT) on interferon therapy against hepatitis C virus, it is hesitated because of the risk for provocation of rejection. Herein initial outcome of our strategy, i.

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Introduction: Obturator hernia is an important cause of small bowel obstruction and is associated with difficult diagnosis and high mortality.

Materials And Methods: We reviewed 22 cases of intestinal obstruction due to obturator hernia that necessitated surgical intervention over the last 17 years and evaluated the changes in the number of patients based on the census data.

Results: All cases were elderly females.

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We report a patient with hyperplastic polyposis who had two asynchronous colon cancers, a combined adenoma-hyperplastic polyp, a serrated adenoma, and tubular adenomas. Hyperplastic polyposis is thought to be a precancerous lesion; and adenocarcinoma arises from hyperplastic polyposis through the hyperplastic polyp-adenoma-carcinoma sequence. Most polyps in patients with hyperplastic polyposis present as bland-looking hyperplastic polyps, which are regarded as non-neoplastic lesions; however, the risk of malignancy should not be underestimated.

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