Modeling urbanization dynamics by labor force migration.

Individual participants in human society collectively exhibit aggregation behavior. In this study, we present a simple microscopic model of labor force migration based on the active Brownian particles framework. In particular, agent-based simulations show that the model produces clusters of agents from a random initial distribution.

Onset of Intragroup Conflict in a Generalized Model of Social Balance.

Dynamically changing interpersonal relationships lie at the core of the emergence of in-group structures, such as polarity or conflict. We explore these dynamics in a simple continuous dynamical model obtained by generalizing a previously proposed model based on Heider's balance theory from social psychology. Previous findings include a rigorous proof of the emergence of in-group harmony or bipolar conflict (global minima) and the identification of local minima called jammed states, along with their corresponding energy spectrum in terms of structural complexity.

Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice.

Serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and DOI exert a hallucinatory effect through serotonin 5-HT receptor (5-HT2A) activation. Recent studies have revealed that serotonergic psychedelics have therapeutic potential for neuropsychiatric disorders, including major depressive and anxiety-related disorders. However, the involvement of 5-HT2A in mediating the therapeutic effects of these drugs remains unclear.

Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice.

Serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and DOI exert a hallucinatory effect through serotonin 5-HT 2A receptor (5-HT2A) activation. Recent studies have revealed that serotonergic psychedelics have therapeutic potential for neuropsychiatric disorders, including major depressive and anxiety-related disorders. However, the involvement of 5-HT2A in mediating the therapeutic effects of these drugs remains unclear.

Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases.

Sphingosine-1-phosphate (S1P) is a lipid mediator that is relatively abundant in plasma and plays an important role in the vascular and immune systems. To date, the only known mechanism for removing S1P from plasma has been dephosphorylation by phospholipid phosphatases (PLPPs) on the surface of cells in contact with the plasma. However, there remains a possibility that PLPP-independent dephosphorylation or direct S1P uptake into cells could occur.