Biomechanical comparison of lag screw and non-spiral blade fixation of a novel femoral trochanteric nail in an osteoporotic bone model.

There is no consensus regarding the advantages of the lag screw type over the blade type for treating femoral trochanteric fractures. We aimed to investigate whether non-spiral blade (Conventional-Blade, Fid-Blade) nails provide better biomechanical fixation than lag screws in a severe osteoporotic bone model. Different severities of osteoporotic cancellous bone were modelled using polyurethane foam blocks of three densities (0.

Prevention of osteonecrosis by intravenous administration of human peripheral blood-derived CD34-positive cells in a rat osteonecrosis model.

Aseptic idiopathic osteonecrosis of the femoral head is a painful disorder of the hip that can lead to collapse of the femoral head and the need for total hip replacement following joint destruction. Treatment of this disease still remains a clinical challenge. Adult human circulating CD34(+) cells have been demonstrated to contribute to vasculogenesis and osteogenesis in immunodeficient rat non-union models in vivo.

Transplantation of bone marrow mononuclear cells enables simultaneous treatment with osteotomy for osteonecrosis of the bilateral femoral head.

Background: Bone marrow derived mononuclear cells (BMMNCs) have the advantage of promoting both angiogenesis and osteogenesis. In this report, BMMNCs were transplanted into the affected area of one hip using interconnected porous calcium hydroxyapatite (IP-CHA) in two patients, while the other hip was simultaneously treated with transtrochanteric rotational osteotomy (TRO). This case report documents the potential of BMMNCs with IP-CHA for bone repair at the lesion of osteonecrosis of the femoral head.

Multiple drillings of the acetabular fossa induce early joint remodeling after rotational acetabular osteotomy for hip dysplasia.

Introduction: We previously observed medial and/or lateral expansion of the subchondral bone in the acetabulum 3 years postoperatively in two out of three cases in which rotational acetabular osteotomy (RAO) was performed. Then we performed multiple drillings at the acetabular fossa in order to induce expansion of the medial subchondral bone in the acetabulum. The purpose of this study is to evaluate the effect of multiple drillings on early joint remodeling after RAO.

Rotational acetabular osteotomy for advanced osteoarthritis secondary to dysplasia of the hip. Surgical technique.

Background: Satisfactory intermediate and long-term results of rotational acetabular osteotomy for the treatment of early osteoarthritis secondary to developmental dysplasia of the hip have been reported. The purpose of this study was to examine the results of rotational acetabular osteotomy in patients with advanced osteoarthritis secondary to developmental dysplasia of the hip.

Methods: We performed a retrospective review of the results of rotational acetabular osteotomy in forty-three patients (forty-three hips).

[Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow mononuclear cells].

Idiopathic osteonecrosis of the femoral head commonly develops during adolescence and in the prime of adulthood. In Japan, joint-preserving procedures such as transtrochanteric rotational osteotomy, femoral varus osteotomy and vascularized bone grafting are often the surgical treatments of choice. However, the results of these procedures are not necessarily satisfactory.

Rotational acetabular osteotomy for advanced osteoarthritis secondary to dysplasia of the hip.

Background: Satisfactory intermediate and long-term results of rotational acetabular osteotomy for the treatment of early osteoarthritis secondary to developmental dysplasia of the hip have been reported. The purpose of this study was to examine the results of rotational acetabular osteotomy in patients with advanced osteoarthritis secondary to developmental dysplasia of the hip.

Methods: We performed a retrospective review of the results of rotational acetabular osteotomy in forty-three patients (forty-three hips).

The Effects of lithium and Zinc Ions on the Pattern of Acidic Glycans in the Sea Urchin (Hemicentrotus pulcherrimus) Embryo: (sea urchin embryo/lithium/zinc/acidic glycan/UEA-I).

Among several acidic glycan components found in Hemicentrotus embryos, the "F"- and "S"-components were specifically affected by treatment with Li and Zn , respectively. The amount of the "F"-component in Li -treated embryos was about 60% that in normal embryos. This fact was in accordance with the reduced alcian blue staining of the surfaces in Li -treated embryos.

Melittin, a Component of Bee Venom, Activates Unfertilized Sea Urchin Eggs: (melittin/activation/sea urchin egg).

Melittin, which is known to stimulate phospholipase A, in many cells, caused as much elevation of fertilization membranes and increase in respiration of unfertilized eggs of the sea urchins Anthocidaris crassispina and Hemicentrotus pulcherrimus as normal fertilization. In melittin-activated eggs, amino acid transport was decreased to less than that of unfertilized eggs, nucleoside transport was only slightly, activated, protein synthesis was rather inhibited and neither DNA synthesis nor cleavage was observed. It is concluded that although melittin induces the cortical reaction and activation of respiration in unfertilized eggs, its cytotoxicity prevents any "late changes".

GENERAL PATTERN, SO -INCORPORATION AND INTRACELLULAR LOCALIZATION OF GLYCANS IN DEVELOPING SEA URCHIN (ANTHOCIDARIS) EMBRYOS.

Glycosaminoglycan (GAG) prepared from sea urchin embryos (Anthocidaris crassispina) at various stages with or without pulse SO -labelling was separated into various fractions by chromatography on DEAE-cellulose with a linear NaCl concentration gradient: fraction "P" (nonacidic) and fractions "A" through "F" (of increasing acidities). The SO -radioactivity was negligible in "P" and "A", largest in "B" and "C", and decreased in the other fractions three alphabetical order. During development (hatched blastulae to gastrulae) the glycans in fractions "P" and "A" decreased in amount, whereas those in "E" and "F" increased.