Synopsis of recent research by authors named "Hiroshi Kogen"
- Hiroshi Kogen's research focuses primarily on the total synthesis of complex natural products and their stereochemical assignments, utilizing innovative synthetic methodologies to achieve enantioselectivity and structural elucidation.
- Notable findings include the establishment of the structures of euvesperins A and B, as well as the first enantioselective total synthesis of rubrobramide and talaramide, which exhibited potential inhibition against amyloid-β aggregation relevant to Alzheimer's disease.
- Kogen's work also highlights advancements in the synthesis of bioactive compounds, such as paraphaeosphaeride C and pleofugin A, revealing their inhibitory activities relevant to diseases, thus contributing valuable insights into medicinal chemistry.
