Publications by authors named "Hiroshi Ishiguro"

This study employs Conversation Analysis to create a recursive model that improves the quality of human-robot interaction. Our research goal is to create a dialogue robot that offers pleasant experiences for users, so they are willing to engage in repeated interactions in daily lives. While there has been dramatic progress in the performance of dialogue robots, there has been less attention to the importance of users' interactional experience compared to the "specs" of the dialogue system.

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Cybernetic avatars integrate physical and virtual avatars to enhance human capabilities in diverse scales and contexts.

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  • Neoadjuvant treatment with microtubule inhibitors (MTIs) for triple negative breast cancer (TNBC) is not well understood, prompting a study that analyzed tumor samples to correlate genetic mutations with treatment response.
  • The study found that tumors with high homologous recombination deficiency (HRD) and specific mutations (like BRCA2) had higher rates of complete response to MTIs like eribulin and paclitaxel.
  • Transcriptomic profiling highlighted FGFR2 downregulation as a critical gene linked to treatment response and identified a significant pathway (glycan degradation) that could influence resistance to these therapies in TNBC patients.*
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  • - The study highlights how childcare leave can hinder the training of early-career psychiatrists in Japan, leading to the development of a teleoperated robot system (Sota) that allows them to learn remotely while on leave.
  • - A case study is presented where a young psychiatrist used Sota to observe and communicate with a board-certified psychiatrist during a patient examination, enhancing her learning about Tourette's syndrome while at home.
  • - The findings indicate that this teleoperated system is beneficial for ongoing professional development during childcare leave, and future research is encouraged to further assess its effectiveness and impact over time.
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  • Medical care on isolated islands is challenging, but telepsychiatry may increase access to psychiatric services using video conferencing and the teleoperated robot "Sota 100" for nonverbal communication.
  • The case of a patient with alcohol use disorder illustrated how Sota 100 facilitated a conversation between the patient, a primary care physician, and a psychiatry specialist, leading the patient to recognize the need to stop drinking to improve health and relationships.
  • Findings suggest Sota 100 is a valuable tool for telepsychiatry in treating alcohol use disorder, and future studies should focus on detailed experimental designs to assess its effectiveness over time.
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The most common CFTR mutant in cystic fibrosis (CF), ΔF508 CFTR, is eliminated by ubiquitination even in the presence of CF drugs, reducing their therapeutic efficacy. RFFL is one of the ubiquitin ligases that remove ΔF508 CFTR from the cell surface despite treatment with the triple combination of CFTR modulators (TEZ/ELX/IVA) used clinically. Although RFFL knockdown has been shown to enhance the efficacy of TEZ/ELX/IVA in cell culture models, its impact in mouse models has not been evaluated.

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Purpose: This study aimed to determine whether the 21-Gene Breast Recurrence Score® assay from primary breast tissue predicts the prognosis of patients with hormone receptor-positive and human epidermal growth factor 2-negative advanced breast cancers (ABCs) treated with fulvestrant monotherapy (Group A) and the addition of palbociclib combined with fulvestrant (Group B), which included those who had progression in Group A from the Japan Breast Cancer Research Group-M07 (FUTURE trial).

Methods: Progression-free survival (PFS) and overall survival (OS) were compared using the log-rank test and Cox regression analysis based on original recurrence score (RS) categories (Low: 0-17, Intermediate: 18-30, High: 31-100) by treatment groups (A and B) and types of ABCs (recurrence and de novo stage IV).

Results: In total, 102 patients [Low: n = 44 (43.

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Language models (LMs) continue to reveal non-trivial relations to human language performance and the underlying neurophysiology. Recent research has characterized how word embeddings from an LM can be used to generate integrated discourse representations in order to perform inference on events. The current research investigates how such event knowledge may be coded in distinct manners in different classes of LMs and how this maps onto different forms of human inference processing.

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Background: Data on the incidence, timing, and severity of myocardial damage after anthracycline-based chemotherapy (AC) in Japanese patients with breast cancer are limited.

Method: We evaluated cancer therapy-related cardiac dysfunction (CTRCD) in Japanese women with breast cancer (n = 51) after the first AC according to the definitions of the 2022 European Society of Cardiology onco-cardiology guideline, including assessment of high-sensitivity troponin I (TnI) and B-type natriuretic peptide (BNP) levels.

Results: CTRCD was detected in 67 % of the patients (3.

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In recent years, the development of robots that can engage in non-task-oriented dialogue with people, such as chat, has received increasing attention. This study aims to clarify the factors that improve the user's willingness to talk with robots in non-task oriented dialogues (e.g.

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Background: Robots offer many unique opportunities for helping individuals with autism spectrum disorders (ASD). Determining the optimal motion of robots when interacting with individuals with ASD is important for achieving more natural human-robot interactions and for exploiting the full potential of robotic interventions. Most prior studies have used supervised machine learning (ML) of user behavioral data to enable robot perception of affective states (i.

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  • - The study explored how animated food, specifically a movable edible robot made from gelatin and sugar, affects human psychology and perceptions of eating.
  • - Participants reacted differently to the robot when it was in motion compared to when it was stationary, influencing their overall impressions and the perceived texture during consumption.
  • - The findings suggest potential applications for edible robots in areas like medicine and culinary experiences, highlighting the psychological impact of animation in food.
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Introduction: Growing anecdotal evidence suggests the feasibility of robotic intervention for people who suffer from disorders related to state anxiety. Few studies have been conducted on utilizing robots for persons who stutter (PWS). The present study examines the feasibility of using a robot for speech therapy for PWS.

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Eribulin is widely used to treat metastatic breast cancer (BC). Higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with higher mortality in several cancer types. However, the association between BC prognosis and peripheral immune status remains controversial.

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  • The use of social robots for communication and entertainment in noisy environments is increasing, but noise negatively impacts human cognition, leading to the implementation of masking sounds.
  • Masking sounds aim to reduce distractions caused by background noise, although they can lead to annoyance and decreased cognitive performance; a study found that altering the frequency of these sounds can lessen annoyance and improve effectiveness.
  • Testing the proposed masking sound during a lecture by a social robot in a noisy setting showed significant improvements in speech comprehension, understandability, and overall satisfaction among listeners, highlighting a need for further research in sound masking within human-robot interactions.
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  • - The study explores using humanoid robots for interviews with depressed patients, hypothesizing that patients might feel more comfortable discussing their issues with robots than with humans due to stigma and shame.
  • - Researchers compared the effectiveness of robot and human interviews by evaluating 13 patients with major depressive disorder and 27 healthy volunteers, finding no significant difference in the reliability of depression assessments between the two methods.
  • - Results indicated that robot interviews specifically helped reduce feelings of shame in patients, suggesting that they could be a valuable tool for assessing depression and encouraging open discussions in clinical practice.
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  • - The study investigated the impact of adding cisplatin (CDDP) to preoperative chemotherapy for patients with triple-negative breast cancer (TNBC), comparing its effects to a group that did not receive CDDP.
  • - A total of 138 previously untreated TNBC patients were analyzed, with the CDDP group showing significantly improved distant disease-free survival (DDFS) rates compared to the non-CDDP group.
  • - The findings suggest that CDDP-containing regimens could improve outcomes for operable TNBC patients, particularly those with higher residual cancer burden, indicating a need for further confirmation in future studies.
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The number of older adults living alone is rapidly increasing. Loneliness in older adults not only degrade their quality of life but also causes troubles such as heavy burden on the medical staff, especially when cognitive decline is present. Social robots could be used in several ways to reduce such problems.

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The increasing need for human-robot interaction requires not only robots to understand how humans think, but also humans to understand robots. Interestingly, little attention has been given to how humans interpret robots' behaviors. In this study, we adopted a social mental rotation task and investigated whether socially engaging behaviors could influence how people take a robot's perspectives.

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  • The study aimed to examine how changes in cell-free DNA (cfDNA) after treatment with palbociclib and fulvestrant might predict clinical outcomes for patients with advanced breast cancer.
  • This analysis involved 56 patients from a prior clinical trial, comparing cfDNA samples taken before treatment and on day 15 of the first treatment cycle.
  • Although there was a significant decrease in the number of mutated genes by day 15, no significant impact on progression-free survival (PFS) was found, suggesting that further research is needed to understand the clinical relevance of cfDNA changes.
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  • Collagen disorders are chronic autoimmune diseases, and their relationship with breast cancer risk is uncertain; this study focused on the outcomes of 25 women with both conditions.
  • The study reviewed patient data, revealing that most had specific types of collagen disorders, and the majority received immunosuppressive treatments.
  • Key findings showed that these patients had higher Ki-67 levels (indicating faster cancer cell growth) and lower rates of recurrence-free survival (RFS) and overall survival (OS) compared to a control group, suggesting the need for close follow-up for these patients.
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  • * To address these challenges, a study introduced a robotic video conference system with two teleoperated robot avatars and compared it to a system using only one avatar.
  • * The results showed that the two-avatar system significantly improved users' RoT and SS, highlighting the impact of robotic technology on communication experiences for individuals with difficulties.
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Purpose: The Phase III POTENT trial demonstrated the efficacy of adding S-1 to adjuvant endocrine therapy for estrogen receptor-positive, HER2-negative early breast cancer. We investigated the efficacy of S-1 across different recurrence risk subgroups.

Methods: This was a post-hoc exploratory analysis of the POTENT trial.

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Introduction: Social skills training (SST) is used to help individuals with autism spectrum conditions (ASC) better understand the perspectives of others and social interactions, develop empathy skills, and learn how to engage with others socially. However, many individuals with ASC cannot easily sustain high motivation and concentration during such an intervention when it is administered by humans. We developed a social skills training program using multiple humanoid robots (STUH), including an android robot, that aimed to enable individuals with ASC to become familiar with the perspectives of others and improve their sociability and empathy skills.

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In recent years, various service robots have been deployed in stores as recommendation systems. Previous studies have sought to increase the influence of these robots by enhancing their social acceptance and trust. However, when such service robots recommend a product to customers in real environments, the effect on the customers is influenced not only by the robot itself, but also by the social influence of the surrounding people such as store clerks.

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