Publications by authors named "Hiroshi Horinosono"
Acral peeling skin syndrome (APSS; MIM 609796) is a rare genodermatosis characterized by painless focal cutaneous exfoliation of the dorsal hands and feet, typically displaying autosomal recessive inheritance. While cases associated with a founder mutation in TGM5 are relatively common in European Caucasian populations, no APSS cases have been reported from Japan or other East Asian countries. In contrast, Nagashima-type palmoplantar keratosis (NPPK; MIM 615598), caused by variants in SERPINB7, is relatively common in East Asia due to founder mutations.
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- A delayed large local reaction (DLLR) is a skin reaction that can occur after receiving the mRNA-1273 COVID-19 vaccine, prompting an investigation into its correlation with sex and age.
- The study, conducted in Tokyo, involved 5893 participants who reported symptoms of DLLR after their first vaccine dose, with interviews led by dermatologists.
- Results showed that 12.7% of participants experienced DLLR symptoms, with a notably higher incidence in females (22.4%) and younger age groups (specifically those aged 30-59), but symptoms were mild and not harmful.
An 89-year-old man presented with an inflammatory erythematous plaque on the left thigh that closely mimicked cellulitis. Empiric therapies with ordinary antibiotics were not effective. A skin biopsy showed epithelioid cell granulomas throughout the dermis and subcutis.
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