Publications by authors named "Hiroshi Hayami"

Article Synopsis
  • The study analyzed antimicrobial susceptibility patterns of 793 bacterial strains from patients with complicated urinary tract infections across eight species, using national surveillance data collected in Japan from July 2020 to December 2021.
  • Fluoroquinolone resistance, particularly among Escherichia coli and Pseudomonas aeruginosa, has risen over the years, with levofloxacin resistance in E. coli increasing from 28.6% in 2008 to 44.5% in 2021, while MRSA vancomycin susceptibility decreased significantly.
  • Extended-spectrum β-lactamase-producing strains were identified in notable proportions, with E. coli (24.8%) and Klebsiella pneumoniae (16
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  • A nationwide surveillance in Japan studied the antimicrobial susceptibility of bacteria in acute uncomplicated cystitis, focusing on E. coli, K. pneumoniae, and S. saprophyticus, between April 2020 and September 2021.
  • The study isolated 823 bacterial strains from urine samples of 848 patients, with a majority being E. coli (92.9%), and determined susceptibility to 18 antibacterial agents.
  • Results showed a concerning increase in fluoroquinolone-resistant E. coli and extended-spectrum β-lactamase (ESBL)-producing E. coli, especially in postmenopausal women, highlighting the need for clinicians to adapt their antibiotic choices due to rising resistance rates.
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Neisseria gonorrhoeae is one of the important pathogens of sexually transmitted infections. N. gonorrhoeae is rapidly becoming antimicrobial resistant, and there are few drugs that are effective in the initial treatment of gonorrhea.

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  • The Urogenital Sub-committee and Surveillance Committee of various Japanese health organizations conducted a nationwide study to assess how susceptible Chlamydia trachomatis is to different antibiotics by collecting clinical samples from 26 hospitals between May 2016 and July 2017.
  • The study measured the minimum inhibitory concentrations (MICs) for a range of antibiotics, finding no resistant strains to fluoroquinolones, tetracyclines, or macrolides, while solithromycin showed particularly favorable MIC values.
  • However, the MIC for azithromycin was slightly higher than in previous reports, suggesting the need for ongoing monitoring of its susceptibility.
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  • A committee from the Japanese Urological Association has created guidelines for infection control in urology, focusing on various aspects of urinary tract management.
  • The guidelines include topics like standard precautions, infection control in urological settings, and strategies to prevent infections during procedures and examinations.
  • The content was developed from a thorough review of medical literature to ensure it provides practical information for clinicians in the field.
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Introduction: The aim of this study was to monitor the development of drug-resistant bacteria isolated from acute uncomplicated cystitis (AUC) and to evaluate methodology of the survey conducted by collecting only clinical data.

Methods: We enrolled female patients at least 16 years of age diagnosed with AUC in 2018. Patient information including age, menopausal status, and results of bacteriological examination were collected and analyzed regardless of bacterial identification, antimicrobial susceptibility testing or extended-spectrum β-lactamase (ESBL) detection method.

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The antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using national surveillance data. The data consisted of 881 bacterial strains from eight clinically relevant species. The data were collected for the third national surveillance project from January 2015 to March 2016 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology.

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The Japanese Surveillance Committee conducted a second nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for acute uncomplicated cystitis (AUC) in premenopausal patients aged 16-40 years old at 31 hospitals throughout Japan from March 2015 to February 2016. In this study, the susceptibility of causative bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus saprophyticus) for various antimicrobial agents was investigated by isolation and culturing of organisms obtained from urine samples. In total, 324 strains were isolated from 361 patients, including E.

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Background: ABO-incompatible living related kidney transplantation (ABO-iLKT) has increased the possibilities for kidney transplantation in patients with end stage renal disease. Due to advancements in immunosuppressive agents and the identification of immunological conditions following ABO-iLKT, this transplantation technique has achieved the same success rate as ABO-compatible LKT. However, some patients continue to generate anti-blood type antibodies, despite conventional immunosuppressant treatment.

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The pathogenesis in the exacerbation of neuromyelitis optica spectrum disorder (NMOSD) involves mainly the serum anti-aquaporin-4 (AQP4) immunoglobulin G antibody (anti-AQP4 antibody). If high-dose corticosteroid treatment is not achieved during remission, rescue plasmapheresis is recommended. However, there are few reports on the therapeutic efficacy of repetitive immunoadsorption plasmapheresis (IAPP) for the recurrent exacerbation of NMOSD with a fluctuating anti-AQP4 antibody level.

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Appropriate policies to improve air quality by reducing anthropogenic emissions are urgently needed. This is typified by the particulate matter (PM) problem and it is well known that one type of PM, sulfate aerosol (SO), has a large-scale impact due to long range transport. In this study we evaluate the source-receptor relationships of SO over East Asia for 2005, when anthropogenic sulfur dioxide (SO) emissions from China peaked.

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After publication of the initial version of the Japanese guidelines for urological surgery in 2007, new surgical techniques have been introduced. Furthermore, several important issues, such as criteria for use of single-dose antimicrobial prophylaxis and control of hospitalized infection, were also established, which led to alterations of the methods used for antimicrobial prophylaxis as well as perioperative management. The purpose of antimicrobial prophylaxis is to protect the surgical wound from contamination by normal bacterial flora.

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  • * A surveillance study conducted in Japan collected urethral discharge samples from patients in 2009 and 2012 to test for antibiotic resistance in C. trachomatis isolates.
  • * Results showed that no resistant strains were found against common antibiotics like fluoroquinolones, tetracyclines, or macrolides during both years of the study.
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Acute kidney injury (AKI) is the main cause of death for victims of hematoxic snakebites. A few studies have described improvement in AKI rates in snakebite cases, but the reasons for the improvement have not been investigated. Eighty-six patients with Protobothrops flavoviridis bites admitted to a single center from January 2003 through March 2014 were included in the study.

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To investigate antimicrobial susceptibility patterns of various bacterial pathogens isolated from complicated urinary tract infection (UTI) cases, the Japanese Society of Chemotherapy, the Japanese Association of Infectious Disease, and the Japanese Society of Clinical Microbiology conducted the second nationwide surveillance from January to September 2011. With the cooperation of 42 medical institutions throughout Japan, 1036 strains belonging to 8 clinically relevant bacterial species were collected. Among methicillin-resistant Staphylococcus aureus (MRSA) strain, the vancomycin (VCM) MIC for 5.

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Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study.

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Objectives: To determine current epidemiology and treatment patterns of urogenital tuberculosis in Japan.

Methods: A questionnaire was sent to the urological departments of 1203 Japanese hospitals. Clinical data was reviewed retrospectively; no time range was specified.

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Unlabelled: Improvement of air quality models is required so that they can be utilized to design effective control strategies for fine particulate matter (PM2.5). The Community Multiscale Air Quality modeling system was applied to the Greater Tokyo Area of Japan in winter 2010 and summer 2011.

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We retrospectively investigated the incidence of genitourinary tract infection in 5895 patients who underwent transrectal and/or transperineal prostate biopsy procedure between January and December 2011 at 46 institutions belonging to Japanese Research Group for Urinary Tract Infection (JRGU). The total rate of genitourinary tract infection after prostate biopsy was 0.76%, while that following transrectal procedure was 0.

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Objectives: The increasing prevalence of resistant bacteria such as fluoroquinolone-resistant or extended-spectrum β-lactamase-producing strains in pathogens causing acute uncomplicated cystitis has been of concern in Japan. Faropenem sodium is a penem antimicrobial that demonstrates a wide antimicrobial spectrum against both aerobic and anaerobic bacteria. It is stable against a number of β-lactamases.

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Ifosfamide combined with other antineoplastic agents has been effective in the treatment of osteosarcoma, although adverse effects are reported in the increasing use of ifosfamide. The most serious complications among the ifosfamide intoxications are neurotoxicity and nephrotoxicity. We report on a patient who suffered from ifosfamide-induced neurotoxicity and nephrotoxicity and rhabdomyolysis after chemotherapy, and was successfully treated with blood purification therapy.

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Purpose: To survey the present condition of administration method of the antimicrobial prophylactic (AMP) agents for the perioperative infection in Japan on revising "The Japanese guidelines for prevention of perioperative infections in urologic field (2006)".

Patients And Methods: With the approval of the Japanese Urological Association (JUA) in 2011, all of the principal urological training institutions certified by JUA (n = 836) were encouraged to participate to survey their adherence to the JUA guidelines (published in 2006) for AMP to prevent perioperative infection in urological field, and 446 (53.3%) institutions responded to the questionnaire.

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