Publications by authors named "Hiroshi Fukumitsu"
[A Case of Synchronous Papillary Thyroid Cancer and Breast Ductal Cancer].
Gan To Kagaku Ryoho
February 2024
Occurrences of thyroid cancer and breast cancer metachronously or synchronously are common for women. Explanations for these associations include detection bias, shared hormonal risk factors, and genetic susceptibility, but the etiology behind specific associations is not elucidated well. The importance of the relationship between breast and thyroid cancer will continue to become evident and physicians should be aware of this association in caring for thyroid and breast cancer survivors.
View Article and Find Full Text PDFWe report a successful case of gastric cancer with esophageal hiatal hernia treated by laparoscopic surgery. The patient was a 75-year-old woman who was referred to our hospital with a diagnosis of early gastric cancer with esophageal hiatal hernia. Laparoscopic distal gastrectomy with lymph node dissection and esophageal hiatal hernia repair using primary suture method without mesh were performed simultaneously.
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- Granulocyte colony stimulating factor (G-CSF) improves liver function in patients with severe liver diseases by boosting the growth of liver progenitor cells (HPCs), but how it works is still unclear.
- The study discovered that a protein called opioid growth factor receptor-like 1 (OGFRL1) from bone marrow cells enhances liver regeneration when G-CSF is administered.
- Increasing OGFRL1 levels in monocytes and liver cells showed potential for fostering HPC involvement and liver cell growth, suggesting OGFRL1 could be a promising treatment for advanced liver fibrosis.
Article Synopsis
- A 62-year-old male underwent endoscopic mucosal resection (EMR) followed by hybrid laparoscopic surgery for early rectal cancer located at the distal border of the rectum.
- The surgical procedure included transanal subtotal intersphincteric resection (ISR) and partial external sphincteric resection (ESR) to ensure clean margins, and the patient had no residual tumor or lymph node metastasis in the resected specimen.
- Three months post-surgery, the patient has good anal muscle tone and is preparing for colostomy closure, indicating that the combined ISR and ESR approach may reduce the need for more extensive surgeries for certain rectal cancers.
Article Synopsis
- The study analyzed 972 colorectal cancer patients' survival rates, focusing on stage I, II, and III patients, with detailed comparisons within the stage III categories based on node positivity and tumor size.
- The 5-year relapse-free survival (5Y-RFS) and overall survival (5Y-OS) rates were highest for stage I patients (94.0% and 90.7% respectively) and lowest for stage III patients (63.5% and 65.7%).
- Notable differences in survival rates were found between subcategories of stage III, indicating that the T1/2N1 category should potentially be reclassified as stage IB/Ib instead of stage IIIA in
Article Synopsis
- Recent studies indicate that bone marrow-derived cells help with wound healing in skin by producing collagen type I, but their exact role in the process is still unclear.
- Researchers used transgenic mice with specific genes linked to fluorescent and luciferase markers to track these collagen-producing cells during skin wound healing.
- Findings showed that while most collagen production during healing comes from resident skin cells, some CD45-positive cells from bone marrow do contribute to collagen production in response to bleomycin, indicating a partial role of bone marrow cells in skin repair.
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- A temporary loop colostomy (TLC) was created before performing radical surgery using a hybrid 2-port method (Mukai's operation), which helps in access during surgery.
- Various surgeries were performed, including left hemicolectomy, sigmoidectomy, low anterior resection, and Hartmann's operation, but one patient with distant metastases did not undergo surgery.
- Overall, the procedure showed favorable outcomes, with manageable operating times, limited blood loss, and a low incidence of complications, suggesting that this method is a safe and effective option for treating advanced left colon or rectal cancers.
Article Synopsis
- * Colon cancer surgeries had a mean operating time of 2 hours 26 minutes and a mean blood loss of 166.3 ml, while rectal cancer surgeries took longer (3 hours 38 minutes) with higher blood loss (238.8 ml) and more complications.
- * The study suggests that HALS may become a standard treatment for colorectal cancer, recommending further research on its long-term outcomes compared to traditional laparotomy.
Article Synopsis
- The study evaluated the impact of adding CPT-11 to standard chemotherapy (5-FU/LV) in 94 patients with stage III colorectal cancer after surgery.
- The results showed that patients with stage IIIa cancer benefited significantly, with higher relapse-free survival rates when treated with the combination (FLC group) compared to those who received only standard treatment (FL group).
- For stage IIIb patients, there were no significant improvements in survival rates with the addition of CPT-11, indicating that the combined treatment is more effective for stage IIIa cases specifically.
Background & Aims: Recent studies have reported that bone marrow (BM)-derived cells migrating into fibrotic liver tissue exhibit a myofibroblast-like phenotype and may participate in the progression of liver fibrosis. However, their contribution to collagen production has not been fully verified yet. We revisited this issue by using 2 mechanistically distinct liver fibrosis models introduced into transgenic collagen reporter mice and their BM recipients.
View Article and Find Full Text PDFA 67-year-old woman was referred to our department for assessment of a tumor in the right lower abdomen. Advanced cecal cancer invading the urinary bladder was diagnosed, and laparoscopy assisted colorectal surgery (LACS)-hybrid 2-port hand-assisted laparoscopic surgery (HALS) was performed in February 2008. Intraoperative laparoscopic observation revealed direct invasion of the urinary bladder by the primary tumor, so an approximately 6-cm transverse suprapubic incision was made.
View Article and Find Full Text PDFIn July 2008, a 40-year-old man presented to his local physician with diffuse abdominal pain and severe abdominal distension. Impending bowel rupture due to colonic obstruction was strongly suspected. Complete obstruction of the distal sigmoid colon by a tumor was diagnosed, and emergency surgery was performed.
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- Researchers explored a technique to prevent the need for a covering stoma in patients with advanced lower rectal cancer during laparoscopic surgery by adding manual reinforcing sutures at the anastomosis site.
- Two case studies were recorded; one involving a 6 cm tumor which required a covering stoma after surgery, while the second, with a 5 cm tumor, did not need one thanks to the added suturing technique.
- Overall, the study concluded that incorporating trans-anal reinforcing sutures can lead to better outcomes for patients undergoing surgery for advanced lower rectal cancer, reducing the need for a stoma.