Enamel matrix derivative monotherapy versus combination therapy with bone grafts for periodontal intrabony defects: An updated review.

This systematic review evaluated the effectiveness of combining enamel matrix derivative (EMD) with various bone grafts in periodontal regenerative surgery, specifically targeting intrabony defects. Randomized controlled trials with 12-month follow-ups were included. Clinical outcomes assessed included clinical attachment level, probing depth, gingival recession, and radiographic defect fill.

Thyroid hormone-dependent and independent processes of red blood cell transition from larval to adult type during metamorphosis in Xenopus laevis.

Amphibian metamorphosis results in drastic whole-body remodeling. Thyroid hormone (TH) drives most of these metamorphic changes. A prominent event during this remodeling is the red blood cell (RBC) transition from larval to adult forms, which exclusively contain larval and adult hemoglobin, respectively.

The gastrin-releasing peptide/bombesin system revisited by a reverse-evolutionary study considering Xenopus.

Bombesin is a putative antibacterial peptide isolated from the skin of the frog, Bombina bombina. Two related (bombesin-like) peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been found in mammals. The history of GRP/bombesin discovery has caused little attention to be paid to the evolutionary relationship of GRP/bombesin and their receptors in vertebrates.

Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus).

Several regions of the brain and spinal cord control male reproductive function. We previously demonstrated that the gastrin-releasing peptide (GRP) system, located in the lumbosacral spinal cord of rats, controls spinal centers to promote penile reflexes during male copulatory behavior. However, little information exists on the male-specific spinal GRP system in animals other than rats.

Brain Metastasis of Pleural Mesothelioma after a Subarachnoid Hemorrhage.

Malignant pleural mesothelioma (MPM) is an uncommon, fatal neoplasm induced by asbestos exposure. Brain metastases from MPM are extremely rare, with most such cases diagnosed only at the time of autopsy. This report describes what we believe to be the first case of MPM metastasizing to the brain after a subarachnoid hemorrhage, as well as the subsequent surgical removal of the brain metastasis.

Prospective phase II study of cisplatin plus pemetrexed with maintenance of pemetrexed for advanced non-squamous cell non-small cell lung cancer in Japan.

Background: A previous study showed a survival benefit with maintenance therapy with pemetrexed in patients with advanced non-small cell lung cancer (NSCLC). However, it remains unclear whether continuation maintenance therapy with pemetrexed is beneficial in Japanese patients. Here, we present our phase II study that assessed the efficacy and safety of cisplatin plus pemetrexed as induction chemotherapy, followed by maintenance therapy with pemetrexed in advanced NSCLC patients in Japan.

Growth inhibition of thermotolerant yeast, Kluyveromyces marxianus, in hydrolysates from cassava pulp.

In this study, we report the inhibition of Kluyveromyces marxianus TISTR5925 growth and ethanol fermentation in the presence of furan derivatives and weak acids (acetic acid and lactic acid) at high temperatures. Cassava pulp, obtained as the waste from starch processing, was collected from 14 starch factories located in several provinces of Thailand. At a high temperature (42 °C), the cassava pulp hydrolysate from some starch factories strongly inhibited growth and ethanol production of both K.

Dose escalation study of carboplatin-pemetrexed followed by maintenance pemetrexed for elderly patients with advanced nonsquamous nonsmall-cell lung cancer.

Background: This study was designed to determine the recommended dose of carboplatin-pemetrexed in elderly (≥75 years old), chemotherapy-naive patients with advanced nonsquamous nonsmall-cell lung cancer (NSCLC).

Patients And Methods: Patients received escalated doses of carboplatin and pemetrexed every 3 weeks for four cycles. Patients with an objective response and stable disease continued pemetrexed therapy until disease progression or unacceptable toxicity was observed.

Medial marginal fracture of the patella following patellar dislocation.

Among patients with patellar dislocation, a small fragment is occasionally found along the medial border of the patella. However, the detailed pathology of this fracture has not been clearly described, especially in relation to the medial patellofemoral ligament (MPFL). The purpose of this study was to describe the pathology of this fracture in relation to the MPFL.

Photon-, electron-, and proton-induced isomerization behavior of ferrocenylazobenzenes.

3-, 4-, and 2-ferrocenylazobenzenes, 1, 2, and 3, respectively, and several derivatives of 1 were synthesized, and their photoisomerization behaviors were examined. The molecular structures of 1 and its derivatives, 2-chloro-5-ferrocenylazobenzene (5) and 3-ferrocenyl-4'-hydroxylazobenzene (11), were determined by X-ray diffraction analysis. 3-Ferrocenyl compound 1 undergoes reversible trans-to-cis isomerization with a single green light source and the Fe(III)/Fe(II) redox change.

Conservative treatment for rugby football players with an acute isolated posterior cruciate ligament injury.

We investigated the outcome of the conservative treatment from the point of athletic performance for rugby football players with an acute isolated PCL injury. The subjects were sixteen competitive rugby football players, with an average age of 21 years. After exercise consisting of quadriceps muscle strengthening and range of knee motion, the players were allowed to return to sports activity when swelling and pain disappeared.

Augmentation with a Gore-Tex patch for repair of large rotator cuff tears that cannot be sutured.

The objective of this study was to determine the effectiveness of augmentation with a Gore-Tex patch in reconstruction of rotator cuff tears that cannot be repaired by direct suture. Twenty-eight shoulders of 27 patients underwent this procedure. The average age at surgery was 62 years, the average duration of symptoms before surgery was 16 months, and the average follow-up period was 44 months.

Redox-conjugated reversible isomerization of ferrocenylazobenzene with a single green light.

A new reversible isomerization cycle for meta-ferrocenylazobenzene accomplished by combination of a single green light (546 nm) and redox change between Fe(II) and Fe(III) was discovered. In the Fe(II) state, trans-to-cis isomerization proceeded upon the green light irradiation exciting the metal-to-ligand charge transfer (MLCT) in a high quantum yield (Phit-->c = 0.51) which exceeds that of azobenzene (Phit-->c = 0.

Longer immobilization extends the "symptom-free" period following primary shoulder dislocation in young rugby players.

The purpose of this study was to evaluate the effect of longer immobilization following primary shoulder dislocation in young rugby players for the prevention of recurrence. We sent a questionnaire regarding shoulder dislocation to all senior high school and college rugby teams in the southwest region of Japan. We received replies from 5476 players in 196 teams (i.

Knee dislocation following anterior cruciate ligament disruption without any other ligament tears.

We report a rare case of complete knee dislocation following anterior cruciate ligament (ACL) disruption without any other ligament tears. The pathology of the knee joint was torn ACL, intact other ligaments, osteochondral fractures and bone bruise of the lateral femoral condyle, and torn lateral meniscus. In this case, osteochondral fracture resulting from the anteriorly sublaxiation of the tibia following ACL disruption was considered to prevent from spontaneous reduction.

Evaluation of surgeries for rheumatoid shoulder based on the destruction pattern.

Objective: To identify the optimal treatment of rheumatoid shoulder, we analyzed the clinical results of shoulder surgeries according to each type of shoulder destruction pattern.

Methods: Forty-seven shoulder surgeries for rheumatoid arthritis (18 arthroscopic synovectomies, 10 total shoulder replacements, 19 humeral head replacements) were assessed clinically and compared in regard to 5 different destruction patterns of rheumatoid shoulder (nonprogressive, arthrosis-like, erosive, collapse, and mutilating patterns).

Results: For nonprogressive-type shoulders, we were able to obtain both pain relief and range of motion (ROM) improvement with arthroscopic synovectomy.

Indicators of superior glenoid labral detachment on magnetic resonance imaging and computed tomography arthrography.

The magnetic resonance imaging and computed tomography arthrographic findings of 36 shoulders with arthroscopically diagnosed detachment of the superior labrum were compared with those of 40 shoulders with a normal superior labrum to detect any findings specific to the injury. In this study we defined a specific magnetic resonance imaging finding as the presence of a linear, high-to-intermediate intensity area between the superior labrum and the glenoid rim on oblique coronal T2-weighted images. We also defined a specific computed tomography arthrography finding as air entering between the superior labrum and the upper part of the glenoid surface.

Treatment for congenital synostosis of the fourth and fifth metacarpals with the hemicallotasis technique.

The hemicallotasis technique was used to treat the fifth metacarpal in a hand with congenital synostosis of the fourth and fifth metacarpals. Lengthening and correction of the metacarpal were achieved simultaneously. Continuous traction eliminated further soft-tissue procedures.

Shoulder destruction in rheumatoid arthritis. Classification and prognostic signs in 83 patients followed 5-23 years.

We studied the natural course and the possibility of making prognoses about shoulder joint destructions in 83 patients with rheumatoid arthritis (RA) (166 shoulder joints). For this purpose, we used radiographic patterns and 2 indices (upward migration and medial displacement). The patterns of joint destruction were classified into 5 groups: 1) non-progressive type (n 74) with normal radiographs, only osteopenia or small erosions even after 15-20 years of RA; 2) erosive type (n 22) showing marginal erosions but no collapse; 3) collapse type (n 34) showing subchondral cysts, followed by collapse; 4) arthrosis-like type (n 12) showing arthrotic features; 5) mutilating type (n 14) showing mutilating bone destructions.

MRI of early osteonecrosis of the femoral head after transcervical fracture.

We have carried out a prospective study of 17 patients (14 women, 3 men) of mean age 48 years (21 to 76) with transcervical fractures of the femur using MRI to detect early evidence of avascular necrosis of the head. Two fractures were Garden stage I, 12 stage II, and three stage III. We performed internal fixation under radiological control at a mean of five days (2 to 15) after injury using a titanium cannulated cancellous screw or a titanium compression hip screw.

Effect of early synovectomy on the course of rheumatoid arthritis.

Ninety-one patients with rheumatoid arthritis were retrospectively assigned to 3 subsets according to the number of joints with erosion (NJE). The subsets were least erosive (LES); more erosive (MES); most erosive involving multilating disease (MUD). In the early stages of disease the subsets were distinct (p less than 0.

Arthroscopic stapling for detached superior glenoid labrum.

Superior labral tears of the shoulder involve the biceps tendon and labrum complex which may be detached, displaced inferiorly, and interposed between the glenoid and the humeral head. We have treated ten young athletes with painful shoulders due to this lesion by arthroscopic stapling. Arthroscopy at the time of staple removal, after three to six months, showed that all the lesions had been stabilised.

[Repair of rabbit articular surfaces with allografts of chondrocytes embedded in collagen gels].

In an attempt to restore articular cartilage, allogeneic articular chondrocytes embedded in collagen gels were transplanted onto full-thickness defects in rabbit articular cartilage. Within 24 weeks after the transplantation, the defects were filled with hyaline cartilage, specifically synthesizing type II collagen. These chondrocytes were autoradiographically proven to be originated from the originally transplanted chondrocytes.