Publications by authors named "Hironori Sagawa"
Objective: To clarify the necessity of acetylsalicylic acid (ASA) administration combined with intravenous immunoglobulin (IVIG) therapy in the treatment of acute Kawasaki disease.
Design: Retrospective cohort study.
Setting: Multicentre.
The aim of this study was to establish a simple and reproducible antegrade perfusion method for isolating single viable mouse heart cells and to determine the standard practical protocols that are appropriate for mice of various ages. Antegrade perfusion was performed by injecting perfusate from near the apex of the left ventricle of the excised heart, the aorta of which was clamped, using an infusion pump. This could thoroughly perfuse the myocardium through the coronary circulation.
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- The study investigates the effects of verapamil and other L-type Ca channel blockers on heart cells from mice of different ages, specifically looking for age-related sensitivity differences.
- Results showed that while all three drugs effectively blocked calcium currents, verapamil was notably more potent in younger mice (up to 21 days old) compared to older mice (28 days and older).
- This increased sensitivity to verapamil in younger mice may help explain the risk of hypotension seen in neonates and infants treated with this medication.
Article Synopsis
- The study examined the correlation between electrocardiographic signs and blood flow ratios in children with atrial septal defects.
- A total of 100 patients were analyzed, revealing that those with right bundle branch block (RBBB) and isolated negative T-waves had higher Qp/Qs ratios, indicating significant blood flow differences.
- Post-surgery, the prevalence of these electrocardiographic signs significantly decreased, suggesting improvements in heart function after repair of the defect.