Early Diagnosis of WEBINO (Wall-Eyed Bilateral Internuclear Ophthalmoplegia) Syndrome Using Thin-Slice Gapless Diffusion-Weighted Imaging in an Acute Ischemic Stroke Patient: A Case Report.

We report a case of acute ischemic stroke presenting as wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome. A 71-year-old woman experienced transient diplopia, followed by the sudden onset of binocular misalignment, gait instability, and nausea. Neurological examination demonstrated exotropia and bilateral adduction impairment, consistent with WEBINO syndrome.

Efgartigimod treatment for generalized myasthenia gravis: a single-center case series of 16 patients.

Background: Efgartigimod was approved in Japan in January 2022 for the treatment of generalized myasthenia gravis (gMG), regardless of antibody status. This case series describes a real-world experience in Japan of efgartigimod treatment for gMG patients with diverse backgrounds.

Methods: We retrospectively analyzed the medical records of 16 Japanese patients (11 females and five males, mean age 40.

Delayed cerebral complications associated with endovascular catheter coil embolization for pulmonary venous shunts mimicking cerebral inflammatory diseases.

Introduction: Hydrophilic polymer embolism in the brain is a delayed complication of cerebral angiography or endovascular therapy. Herein, we report a rare case of a hydrophilic polymer embolism in the brain due to endovascular catheter coil embolization of pulmonary venous shunts.

Case Report: A 16-year-old female presented with headache, dizziness, nausea, and dysesthesia in the left upper limb.

Patterns of Reacted Adatoms in Adsorption of Acetonitrile on Si{111}-(7 × 7).

We report on the covalent binding of acetonitrile (CHCN) on Si{111}-(7 × 7) at ∼300 K studied by scanning tunneling microscopy, thermal desorption spectroscopy, and first-principles theoretical calculations. The site-specific study makes it possible to unravel the site-by-site and step-by-step kinetics. A polarized CHCN prefers to adsorb on the faulted half more frequently compared to on the unfaulted half.

SIRT7 Deficiency Protects against Aβ-Induced Apoptosis through the Regulation of NOX4-Derived Reactive Oxygen Species Production in SH-SY5Y Cells.

Alzheimer's disease (AD) is an age-related neurodegenerative disease that is characterized by irreversible memory loss and cognitive decline. The deposition of amyloid-β (Aβ), especially aggregation-prone Aβ, is considered to be an early event preceding neurodegeneration in AD. Sirtuins (SIRT1-7 in mammals) are nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases, and several sirtuins play important roles in AD.

Adsorption of Acetonitrile on Si(111)-(7 × 7).

The adsorption of acetonitrile (CHCN) on Si(111)-(7 × 7) at a room temperature has been investigated using scanning tunneling microscopy (STM) and first-principles calculations. The site-specific information on adsorption enables us to understand the site-by-site and step-by-step adsorption mechanism. From theoretical simulations, the most stable configuration of CHCN on Si(111)-(7 × 7) is found to be a molecularly chemisorbed CHCN with the carbon and nitrogen atoms of CN bonded to the rest atom and adatom on the Si surface, respectively.

CSF TACI and BAFF levels in patients with primary CNS lymphoma as novel diagnostic biomarkers.

We used an enzyme-linked immunosorbent assay to measure pretreatment B cell-activating factor belonging to the tumour necrosis factor family (BAFF) and transmembrane activator and CAML-interactor (TACI) levels in CSF and serum collected from patients with primary central nervous system lymphoma (PCNSL) and control groups. The decision tree analysis of CSF TACI and BAFF levels for patients with a PCNSL diagnosis showed 100% sensitivity and 100% specificity when we attempted to differentiate PCNSL from glioblastoma and CNS inflammatory diseases. The combination of CSF TACI and BAFF levels may thus be a novel and useful diagnostic biomarker of PCNSL.

[Embolic stroke immediately after initial administration of intravitreal aflibercept].

A 72-year-old man was admitted to our hospital because of right upper limb monoplegia 8 hours after the initial intravitreal injection of aflibercept, which is an inhibitor of vascular endothelial growth factor. Magnetic resonance diffusion-weighted images showed recent ischemic lesions in the left corona radiata and the right superior frontal gyrus. Laboratory findings showed mild hyperfibrinolysis.

Serum levels of leptin receptor in patients with malignant melanoma as a new tumor marker.

Leptin is known to be abnormally expressed in a variety of cancers, and leptin receptors have been reported to be expressed on human melanoma cells. In this study, we evaluated the possibility that the serum levels of leptin receptor could be a tumor marker of malignant melanoma (MM). Serum samples were obtained from 71 patients with MM, and the serum levels of leptin receptor were measured by double-determinant ELISA.