Publications by authors named "Hironari Ito"
Article Synopsis
- Tyrosinase is crucial for melanin synthesis but its transport within cells may be linked to conditions like albinism, although specific transport mechanisms are not fully understood.
- The compound 4-OST significantly inhibits melanin production in melanoma cells by reducing the protein levels of tyrosinase without impacting its mRNA or activity; it also induces an increase in a lysosomal protein called cathepsin S.
- Treatments with lysosome inhibitors, like chloroquine, can reverse the downregulation of tyrosinase caused by related compounds, suggesting 4-OST and GIF-2202 might redirect tyrosinase to lysosomes instead of melanosomes, providing insights into tyrosinase transport pathways.
Azepine derivative T4FAT, a new copper chelator, inhibits tyrosinase.
Biochem Biophys Res Commun
January 2019
Melanin plays an important role in the protection of the skin from ultraviolet irradiation. However, excessive melanin deposition leads to hyperpigmentation and freckles, which are recognized as skin problems, and signs of aging. Tyrosinase, a copper-containing protein, is the rate-limiting enzyme in melanin biosynthesis and first catalyzes the hydroxylation of l-tyrosine to 3,4-dihydroxyphenylalanine (DOPA) and the further oxidization to dopaquinone.
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