Publications by authors named "Hiromu Yanagisawa"

Adrenomedullin (AM) exerts strong pulmonary vasodilatory effects. These effects are mediated in part by nitric oxide. Plasma AM levels are increased in patients with pulmonary hypertension and correlate with disease severity and poor outcomes.

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Article Synopsis
  • Researchers found that NRSF (neuron restrictive silencer factor) helps maintain normal heart function by suppressing a fetal cardiac gene program that can lead to heart failure.
  • They conducted studies using mice to analyze the role of NRSF and its effects on the gene Gα, which was linked to worsening cardiac function when overexpressed.
  • The study concluded that targeting Gα might provide new therapeutic options for treating heart failure by improving calcium handling in heart cells.
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In Japan, transcatheter aortic valve implantation (TAVI) with Edwards-SAPIEN XT valve (Edwards Lifesciences Inc., Irvine, CA, USA) started in October 2013. All institutions should undergo a training period to perform TAVI independently.

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