Control of tissue size and development by a regulatory element in the 3'UTR.

Regulation of the Hippo pathway via phosphorylation of Yorkie (Yki), the homolog of human Yes-associated protein 1, is conserved from to humans. Overexpression of a non-phosphorylatable form of Yki induces severe overgrowth in adult fly eyes. Here, we show that mRNA associates with microsomal fractions and forms foci that partially colocalize to processing bodies in the vicinity of endoplasmic reticulum.