Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophages.

Internalization of modified low-density lipoprotein (LDL) via macrophage scavenger receptors (e.g. scavenger receptor A and CD36) is thought to play a crucial role in the development of atherosclerotic lesions.

Anti-atherosclerotic effect of cilostazol in apolipoprotein-E knockout mice.

To investigate whether cilostazol (CAS 73963-72-1), a selective phosphodiesterase 3 inhibitor, reduces the progression of atherogenic diet-induced atherosclerosis, cilostazol was orally administered twice a day for 4 weeks to male apolipoprotein-E knockout (ApoE KO) mice. In serial sections of the aortic root, the atherosclerotic lesion ratios in the cilostazol-treated groups (32.5 +/- 3.

Effect of G-1 column (Adacolumn) therapy in rats with adjuvant arthritis on the migration and immunoreactivity of peripheral and splenic leukocytes.

The G-1 column (Adacolumn), a novel extracorporeal adsorption device, is now available for the treatment of such chronic inflammatory diseases as ulcerative colitis and rheumatoid arthritis. G-1 column treatment sometimes results in a rapid decrease in clinical inflammatory parameters and/or has a delayed beneficial effect on disease activity. In order to identify the scientific basis for such clinical benefits, we studied rats with adjuvant arthritis induced by immunization with Mycobacterium butyricum antigen.

Nitric oxide (NO) is not involved in accentuated antagonism for chronotropy in the isolated mouse atrium.

Nitric oxide (NO) is reportedly involved in accentuated antagonism in the canine blood-perfused sinoatrial (SA) node, and is thought to modulate cholinergic control of heart rate in rabbits. In the present study, we evaluated the involvement of NO in accentuated antagonism in an isolated preparation of both atria from C57BL/6J mice. Isoprenaline (10(-10) M-10(-7) M) had positive chronotropic effects but decreased rather than increased contraction strength.