Publications by authors named "Hiromi Wai Ling Koh"
Article Synopsis
- Patients with younger onset type 2 diabetes (YT2D) face a higher risk for kidney failure, yet the progression mechanism of diabetic kidney disease (DKD) in this group is not well understood.
- A study involving 144 DKD progressors and 292 non-progressors aimed to find new biomarkers and causal proteins linked to DKD progression in YT2D, utilizing proteomic analysis and logistic regression methods.
- Results identified 42 plasma proteins related to DKD progression, with angiogenin emerging as a significant factor, indicating its potential role in the disease's advancement.
Article Synopsis
- Diabetic corneal neuropathy (DCN) is a common issue for those with diabetes, but there aren't many treatment options available.
- A study on 30 type 2 diabetes patients found that the medication fenofibrate significantly improved nerve regeneration and reduced nerve swelling in the cornea after 30 days.
- The treatment also enhanced the overall health of the ocular surface, as shown by better tear stability and reduced damage to corneal and conjunctival tissues, indicating fenofibrate could be a promising new therapy for DCN.
Randomized controlled trials suggest that protein restriction may retard the progression of CKD toward ESRD. However, the effects of dietary protein intake level and the food sources of dietary protein on the risk of ESRD in the general population remain unclear. We investigated these effects in the Singapore Chinese Health Study, a prospective population-based cohort that recruited 63,257 Chinese adults aged 45-74 years from 1993 to 1998.
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