Publications by authors named "Hiromi Hano"
Blood Cells Mol Dis
February 2025
Article Synopsis
- GATAs are a transcription factor family with six members, where GATA1 and GATA2 are crucial for the development of specific blood cells like erythrocytes and eosinophils.
- The study explores whether growth hormone (GH) acts as an external stimulant for GATA1 expression in blood cell lines, employing various lab techniques to assess this relationship.
- Results indicate that GH enhances GATA1 expression through a pathway involving the GHR/JAK/STAT5 signaling mechanism, indicating its role in the proliferation of hematopoietic cells.
Growth Horm IGF Res
February 2024
Article Synopsis
- GATA2 is a crucial transcription factor for the development of specific cell types in the pituitary and blood systems, but little is known about what activates it.
- The study explored whether growth hormone (GH) stimulates GATA2 expression in pituitary tumor cells and examined the mechanisms involved, specifically focusing on the GHR/JAK/STAT5 signaling pathway.
- Results showed that GH boosts GATA2 levels in a dose-dependent manner through activated STAT5B, indicating that GH directly influences GATA2 and may play a role in various developmental processes.
