Inhibitory effects of incadronate on the progression of rat experimental periodontitis by porphyromonas gingivalis infection.

Background: Incadronate (YM175, disodium cycloheptylaminomethylenediphosphonate monohydrate), a bisphosphonate, has been suggested to prevent the bone resorption associated with periodontitis by inhibiting osteoclast activity. The purpose of this study was to investigate the effect of incadronate in preventing periodontal destruction in rats with Porphyromonas gingivalis-induced periodontitis.

Methods: Periodontitis was induced in 35 Wister rats by inoculating P.