Publications by authors named "Hiroko Yoneda"
A 26-year-old woman with a history of feeling nauseated during dental local anesthesia presented to our clinic for tooth extraction under intravenous sedation. Although she had experienced episodes of neurally-mediated syncope, her symptoms were controlled well with drug therapy, stopped 3 years earlier. No syncope episodes developed over the previous 2 years.
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- The study aimed to compare the effects of sitagliptin and glimepiride on early-phase insulin secretion in Japanese patients with type 2 diabetes over 52 weeks.*
- A total of 171 patients were randomly assigned to either treatment group, and results showed that those on sitagliptin had a significantly higher insulinogenic index and better glucose control during tests compared to those on glimepiride.*
- Overall, sitagliptin was more effective in improving insulin secretion without changing body weight or causing significant hypoglycemia, indicating it may be a preferable treatment option for managing type 2 diabetes in this population.*
The molecular regulatory mechanisms and the characterization of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in hypoxia were studied in a mouse brain capillary endothelial cell line, MBEC4. Activation of GAPDH gene expression by hypoxia was suppressed by an intracellular Ca(2+) chelator and inhibited by a non-selective cation channel blocker or a Na(+)/Ca(2+) exchanger (NCX) blocker. Sequencing of reverse transcription-PCR products demonstrated that MBEC4 expressed an mRNA encoding NCX3, which functions even under cellular ATP-depleted conditions, in addition to mRNAs encoding NCX1 and NCX2.
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