Publications by authors named "Hiroko Nakabayashi"
Article Synopsis
- Diabetic cardiomyopathy (DCM) mainly affects diastolic function and is linked to altered energy usage; PPARα is implicated in this condition and pemafibrate is a selective modulator that could have therapeutic effects.
- In a study with 17 type 2 diabetes patients, pemafibrate was administered for 8-16 weeks, with echocardiography used to evaluate changes in diastolic function metrics like E/A ratio and e'.
- Results showed that pemafibrate significantly improved diastolic function by increasing early diastolic annular velocities (e') and reducing the E/e' ratio, indicating its potential role in preventing DCM in diabetic patients.
Endoplasmic reticulum (ER) stress is a key pathogenic factor in type 1 and 2 diabetes. Glycogen synthase kinase 3 (Gsk-3) contributes to β-cell loss in mice. However, the mechanism by which Gsk-3 leads β-cell death remains unclear.
View Article and Find Full Text PDFAims/introduction: Understanding morning-evening variation in metabolic state is critical for managing metabolic disorders. We aimed to characterize this variation from the viewpoints of insulin secretion and insulin sensitivity, including their relevance to the circadian rhythm.
Materials And Methods: A total of 14 and 10 people without diabetes were enrolled, and underwent a 75-g oral glucose tolerance test (OGTT) and hyperinsulinemic-euglycemic clamp study, respectively.
The liver is the major organ maintaining metabolic homeostasis in animals during shifts between fed and fasted states. Circadian oscillations in peripheral tissues including the liver are connected with feeding-fasting cycles. We generated transgenic mice with hepatocyte specific E4BP4, D-box negative regulator, overexpression.
View Article and Find Full Text PDFIn Wfs1A/a islets, in association with endoplasmic reticulum (ER) stress, D-site-binding protein (Dbp) expression decreased and Nuclear Factor IL-3 (Nfil3)/E4 Promoter-binding protein 4 (E4bp4) expression increased, leading to reduced DBP transcriptional activity. Similar alterations were observed with chemically-induced ER stress. Transgenic mice expressing E4BP4 under the control of the mouse insulin I gene promoter (MIP), in which E4BP4 in β-cells is expected to compete with DBP for D-box, displayed remarkable glucose intolerance with severely impaired insulin secretion.
View Article and Find Full Text PDFArticle Synopsis
- ARNT/HIF-1β is linked to pancreatic β-cell dysfunction and type 2 diabetes, with a significant reduction in Arnt expression observed in type 2 diabetic islets compared to non-diabetic ones.
- The study reveals a connection between Arnt and clock-controlled genes (Dbp and E4bp4) in diabetic mice, indicating altered expressions of these genes along with Arnt in relation to circadian rhythms.
- Overexpression of DBP increases ARNT levels in cultured cells, while E4BP4 inhibits this effect, suggesting that changes in these clock genes contribute to the suppression of Arnt expression in diabetes.
A 68-year-old female complained of anemia and bone pain. Monoclonal increase of plasma IgA, lambda-type was observed, and immature plasma cells were detected in the bone marrow. These plasma cells showed intermediate differentiation on CD38 gating flow cytometry.
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