Publications by authors named "Hiroko Ikuji"
Article Synopsis
- Researchers discovered that a polyphenol from brown algae can inhibit the differentiation of fibroblasts into fat cells, known as adipocytes.
- In an experiment, this compound was given to mice on a high-fat diet, which resulted in reduced fat accumulation, similar to that of mice on a normal diet.
- The study concluded that the Pin1 protein is essential for the conversion of stem cells into adipocytes and suggested that the brown algae polyphenol may offer a potential treatment for obesity.
The peptidyl prolyl cis/trans isomerase Pin1 enhances the uptake of triglycerides and the differentiation of fibroblasts into adipose cells in response to insulin stimulation. Pin1 downregulation could be a potential approach to prevent and treat obesity-related disorders. In order to identify an inhibitor of Pin1 that exhibited minimal cytotoxicity, we established a high-throughput screen for Pin1 inhibitors and used this method to identify an inhibitor from 1,056 crude fractions of two natural product libraries.
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