Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload.

Heart failure has high morbidity and mortality in the developed countries. Autophagy is important for the quality control of proteins and organelles in the heart. Rubicon (Run domain Beclin-1-interacting and cysteine-rich domain-containing protein) has been identified as a potent negative regulator of autophagy and endolysosomal trafficking.

Woven Coronary Artery Anomaly: Optical Coherence Tomography Versus Intravascular Ultrasound.

Woven coronary artery anomaly is a rare congenital anomaly, and intravascular ultrasound and optical coherence tomography are useful for the diagnosis. We performed both imaging techniques for woven coronary artery anomaly and evaluated which was superior. We concluded that optical coherence tomography was the preferred imaging modality in this case.

Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice.

Mitochondrial deoxyribonucleic acid, containing the unmethylated cytidine-phosphate-guanosine motif, stimulates Toll-like receptor 9 to induce inflammation and heart failure. A small chemical, E6446 [(6-[3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl]benzo[d]oxazole)], is a specific Toll-like receptor 9 inhibitor in cardiomyocytes. In this study, we showed that E6446 exerts beneficial effects for the prevention and treatment of pressure overload-induced heart failure in mice.