Publications by authors named "Hiroki Shinchi"
Extracellular vesicles (EVs) in biofluids are highly heterogeneous entities in terms of their origins and physicochemical properties. Considering the application of EVs in diagnostic and therapeutic fields, it is of extreme importance to establish differentiating methods by which focused EV subclasses are operationally defined. Several differentiation protocols have been proposed; however, they have mainly focused on smaller types of EVs, and the heterogeneous nature of large EVs has not yet been fully explored.
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- Chronic liver injury can make the liver work poorly and cause a buildup of scar tissue called fibrosis.
- Researchers found a protein called fibulin-4 that could help identify liver fibrosis in patients, especially those with cirrhosis.
- The study showed that fibulin-4 levels rise with the seriousness of cirrhosis and are linked to other problems like varices (swollen veins) in the liver.
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- Researchers studied liquid biomarkers in patients with EGFR mutation-positive non-small-cell lung cancer receiving gefitinib, analyzing plasma samples to find proteins linked to tumor response and survival outcomes.
- Out of 1769 proteins identified, several were correlated with tumor reduction, progression-free survival (PFS), and overall survival (OS), with notable involvement of immune response regulators.
- CD8α and DOK3 emerged as significant markers, indicating that patients with strong T-cell and B-cell immunity may have better responses to gefitinib therapy.