Publications by authors named "Hiroki Numata"
Article Synopsis
- Lymphoproliferative disorders related to Epstein-Barr virus (EBV-LPDs) can present in different ways, including symptoms resembling infectious mononucleosis and more severe conditions like lymphoma, but the relationship between these presentations is not entirely understood.
- A 61-year-old male patient initially diagnosed with aplastic anemia (AA) showed unusual B-lymphocytes in his blood and was classified with an infectious mononucleosis-like syndrome.
- Although atypical lymphocytes went away, further examinations revealed diffuse large B-cell lymphoma, and despite starting treatment with rituximab, his health deteriorated due to complications, ultimately leading to his death from multiple organ failure caused by a bacterial infection.
Article Synopsis
- The study investigates the relationship between fetal hemoglobin (HbF) levels and prognosis in patients with myelodysplastic syndrome (MDS), analyzing data from 217 diagnosed patients.
- HbF levels were found to be higher in MDS patients compared to a control group, with lower-risk patients showing longer leukemia-free survival (LFS) at intermediate HbF levels.
- The research concludes that intermediate HbF levels may be linked to better outcomes in lower-risk MDS patients, highlighting the importance of HbF in MDS prognosis according to recent WHO criteria.
Article Synopsis
- * HIF-PH inhibitors, like roxadustat, enhance the body's natural production of erythropoietin and improve iron metabolism, showing potential for treating MDS, although their safety and efficacy had been previously untested.
- * A 78-year-old woman with therapy-related MDS experienced significant improvement in anemia and stopped needing blood transfusions after switching from ESAs to roxadustat, with no adverse effects noted in the following four months
A 69-year-old man was diagnosed with chronic myelogenous leukemia (CML) and treated with dasatinib. After two years on dasatinib, the patient achieved complete molecular response, but dasatinib treatment was discontinued due to exacerbation of pleural effusion. Nilotinib and imatinib were started but stopped due to an increase in pleural effusion.
View Article and Find Full Text PDFA 40-year-old male developed refractory acute promyelocytic leukemia (APL) after various treatments including all-trans retinoic acid, tamibarotene, arsenic trioxide (As2O3), conventional chemotherapy, and autologous peripheral blood stem cell transplantation. We attempted to use both tamibarotene and As2O3 as a combination therapy, and he achieved molecular complete remission. Grade 2 prolongation of the QTc interval on the electrocardiogram was observed during the therapy.
View Article and Find Full Text PDFAutoimmune hemorrhaphilia due to anti-factor XIII (FXIII) antibodies (AH13) is a life-threatening disease associated with high risk of surgical bleeding. Since AH13 occurs mainly in the elderly, patients of AH13 tend to be complicated with other life-threatening diseases that may require surgical procedures. During our nation-wide survey on AH13, supported by the Japanese Ministry of Health, Labor, and Welfare, patients with unexplained bleeding were examined for FXIII-related parameters and anti-FXIII autoantibodies.
View Article and Find Full Text PDFDiffuse large B-cell lymphoma (DLBCL) is the most common subtype of malignant lymphoma. The incidence of Epstein-Barr virus (EBV)-positive DLBCL in Asian and Latin American countries ranges from 8 to 10%. The prognosis of patients with EBV-positive DLBCL is controversial.
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