Publications by authors named "Hiroki Nakajima"

We revised the previous records of Clorida japonica Manning, 1978 and conducted extensive field and museum material surveys in Japan. The material examined included five species of the genus Clorida Eydoux & Souleyet, 1842 as follows: C. japonica; C.

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A-kinase anchor protein 12 (AKAP12), a scaffold protein, has been implicated in the central nervous system, including blood-brain barrier (BBB) function. Although its expression level in the corpus callosum is higher than in other brain regions, such as the cerebral cortex, the role of AKAP12 in the corpus callosum remains unclear. In this study, we investigate the impact of AKAP12 deficiency by transcriptome analysis using RNA-sequencing (RNA-seq) on the corpus callosum of AKAP12 knockout (KO) mice.

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  • A study examined the link between changes in estimated glomerular filtration rate (eGFR) and the risk of developing end-stage kidney disease (ESKD) in the general population using data from Japanese health check-ups.
  • Researchers analyzed data from over 115,000 individuals who had their eGFR measured three times between 2013 and 2020, discovering that those with a higher coefficient of variation in eGFR (CVeGFR ≥ 8.5%) had a significantly increased risk of ESKD.
  • The findings suggest that annual variations in eGFR can indicate a higher risk of ESKD, independent of other traditional risk factors, highlighting the importance of monitoring eGFR in health assessments
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  • A nationwide survey in Japan aimed to assess the use of prehabilitation during neoadjuvant chemotherapy (NAC) for patients with advanced esophageal cancer, revealing limited implementation.
  • Out of 155 hospitals surveyed, only 39% offered prehabilitation, with barriers including insufficient human resources, reimbursement issues, and a lack of standardized programs.
  • The study highlights a significant gap in the availability of evidence-based prehabilitation practices, indicating a need for more resources and structured programs for better patient outcomes.
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Background: Emerging evidence has supported the idea that goal-directed prehabilitation is a promising approach to boost functional capacity in preoperative patients. However, its usefulness has not been tested in the hepatobiliary and pancreatic fields. The objective of this trial was to investigate the efficacy of goal-directed prehabilitation for improving functional capacity in patients who were planned to undergo major hepatobiliary and pancreatic operations.

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A new hermit crab species of Paguridae, Trichopagurus spinibrachium n. sp., is described on the basis of a single male specimen collected from the anchialine environment of a semi-submerged marine cave in Okinawa Island, Ryukyu Islands, southwestern Japan.

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  • Obesity is linked to health complications and shorter life expectancy, but distinct subgroups among obese individuals have not been clearly defined.
  • A study used cluster analysis on data from nearly 10,000 individuals with obesity to identify these subgroups based on complications like diabetes and other health issues.
  • Seven unique clusters were found, revealing that individuals with limited healthcare visits post-obesity diagnosis had the worst health outlook, highlighting the need for targeted interventions and recognizing a metabolically healthy obesity group.
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Although antithyroid drug (ATD)-induced agranulocytosis is a significant concern, its risks associated with long-term use and re-administration are not fully elucidated. Therefore, we performed this study to determine the incidence of ATD-induced leukopenia and G-CSF administration using administrative claims database. Retrospective cohort study.

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Vascular cognitive impairment (VCI) refers to cognitive alterations caused by vascular disease, which is associated with various types of dementia. Because chronic cerebral hypoperfusion (CCH) induces VCI, we used bilateral common carotid artery stenosis (BCAS) mice as a CCH-induced VCI model. Transient receptor potential ankyrin 1 (TRPA1), the most redox-sensitive TRP channel, is functionally expressed in the brain.

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Background: Neoadjuvant chemotherapy is a common therapeutic procedure for patients with pancreatic cancer. This study aimed to investigate the association between the total psoas area (TPA) and prognosis in patients undergoing neoadjuvant chemotherapy for resectable or borderline resectable pancreatic cancer.

Study Design: This retrospective study included patients who underwent neoadjuvant chemotherapy for pancreatic cancer.

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  • Multiple endocrinopathies, particularly the rare combination of hypophysitis and type 1 diabetes mellitus (T1DM), can occur as adverse events from immune checkpoint inhibitors (ICIs) like anti-PD-1 antibodies.
  • In a study analyzing three cases along with existing reports, it was found that all patients had specific human leukocyte antigen (HLA) haplotypes linked to hypophysitis, and these cases predominantly affected men in their 60s.
  • The onset of endocrine disorders occurred similarly in both combined and single endocrinopathy cases, indicating no significant difference in the time frame from ICI treatment initiation to disease manifestation, suggesting the need for more research on this condition.
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A new porcellanid species of the genus Enosteoides Johnson, 1970 is described on the basis of a single specimen collected from the burrow of an unidentified snapping shrimp of the genus Alpheus Fabricius, 1798, on the subtidal coarse sediment in Okinawa Island, Ryukyu Islands, southwestern Japan. Enosteoides lapis n. sp.

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Astrocytes are glial cells that serve homeostatic functions in the central nervous system (CNS). Recent research, however, suggests that under pathological conditions, astrocytes are stimulated by various factors and actively participate in CNS inflammation. In the present study, we found that astrocytes upregulate various inflammatory factors including prostaglandin E (PGE ) by co-stimulation with tumor necrosis factor-alpha (TNFα) and interleukin-1alpha (IL1α).

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  • Ectopic ACTH syndrome (EAS) is a rare condition associated with small-cell lung cancer (SCLC), and while chemotherapy helps SCLC, EAS is harder to treat.
  • A 72-year-old male with stage 4B SCLC and EAS showed significant improvement after treatment with atezolizumab and chemotherapy, leading to a reduction in tumor size and hormone levels.
  • EAS patients on atezolizumab and chemotherapy need careful monitoring due to potential adrenal insufficiency and the potent effects of the treatment.
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Background: Despite the associations of both preoperative sarcopenia and physical performance with post-operative mortality in non-small-cell lung cancer (NSCLC), there have been no comprehensive studies of the impact of physical status on prognosis. This study was performed to investigate the prognostic significance of preoperative sarcopenia and physical performance in NSCLC.

Methods: This retrospective cohort study was performed in NSCLS patients undergoing curative lung resection at a university hospital between January 2014 and December 2017.

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Aim: This study aimed to determine whether there is an association between influenza and new-onset type 1 diabetes.

Materials And Methods: This population-based retrospective cohort study used data from the National Database of Health Insurance Claims and Specific Health Check-ups of Japan. Influenza was defined based on drug prescriptions and the onset of type 1 diabetes was defined using specific medical codes indicating a diagnosis of type 1 diabetes.

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Background: Ki67 is a recognized proliferative and predictive marker in invasive breast cancer. However, results of Ki67 evaluation are affected by the method employed for sample fixation or biopsy, as well as by intratumor heterogeneity. Here, we aimed to compare the Ki67 labeling index (Ki67LI) between core-needle biopsy specimens (CNBSs) and surgically resected specimens (SRSs) of invasive breast cancer, and verify whether the discordance in Ki67LI can be reduced by analyzing the maximum standardized uptake value (SUVmax) obtained from pretreatment whole-body positron emission tomography/computed tomography (PET/CT) in combination with Ki67LI.

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Introduction: In Japan, patient-led insulin titration is rare in type 2 diabetes mellitus (T2DM) patients. Few studies have compared the effects of patient-led versus physician-led insulin titration on patient-reported outcomes in Japanese T2DM patients. This study aimed to compare the effects of patient-led and physician-led insulin titration in Japanese insulin-naïve T2DM patients on safety, glycemic control, and patient-reported outcomes (emotional distress, treatment satisfaction, and self-efficacy).

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  • - The study compared the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2is, specifically dapagliflozin) and dipeptidyl peptidase 4 inhibitors (DPP4is) on the quality of life (QOL) of 253 Japanese patients with type 2 diabetes over 24 weeks.
  • - Results showed that a higher percentage of patients in the dapagliflozin group reported improvements in overall QOL (28.4% vs. 18.6%) and significantly better physical health scores when compared to the DPP4i group.
  • - Additionally, patients taking dapagliflozin experienced greater reductions in body weight, BMI, and
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The physiological and behavioral influences of 2.45 GHz microwaves on were examined. Standing waves transitioned into heat energy effectively when passing through the insect body.

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Background And Aims: Complete surgical resection with negative margin is one of the pillars in treatment of liver tumours. However, current techniques for intra-operative assessment of tumour resection margins are time-consuming and empirical. Mass spectrometry (MS) combined with artificial intelligence (AI) is useful for classifying tissues and provides valuable prognostic information.

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Demands for chemical-free treatments for controlling insect pests are increasing worldwide. One such treatment is microwave heating; however, two critical issues arise when using microwaves as a heat source: intensive labor and excessive energy-consumption. Optimization is thus required to reduce energy consumption while effectively killing insects.

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