Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.

Tissue regeneration and maintenance rely on coordinated stem cell behaviours. This orchestration can be impaired by oncogenic mutations leading to cancer. However, it is largely unclear how oncogenes perturb stem cells' orchestration to disrupt tissue.

Revised Cut-Off Value of Human Epididymis Protein 4 Enhances Its Use as an Ovarian Tumor Marker.

Objectives: Human epididymis protein 4 (HE4), a protein secreted by ovarian tumors, has been used as an ovarian tumor marker. This study aimed to improve the usefulness of HE4 to detect malignant ovarian tumors by reviewing the cut-off values.

Design: A retrospective study without intervention was conducted.

First description of a clinical glutamine-dependent Escherichia coli with a missense mutation in the glnA.

Introduction: Small-colony variants (SCVs) of bacteria are subpopulations with a small colony size, low growth rate, and atypical colony morphology. The purpose of this study was to comprehensively elucidate the characteristics and underlying mechanism of the development of a glutamine-dependent SCV of E. coli, GU-92, isolated from the blood of a patient with pyelonephritis.

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.

Inter-tissue interaction is fundamental to multicellularity. Although the basement membrane (BM) is located at tissue interfaces, its mode of action in inter-tissue interactions remains poorly understood, mainly because the molecular and structural details of the BM at distinct inter-tissue interfaces remain unclear. By combining quantitative transcriptomics and immunohistochemistry, we systematically identify the cellular origin, molecular identity and tissue distribution of extracellular matrix molecules in mouse hair follicles, and reveal that BM composition and architecture are exquisitely specialized for distinct inter-tissue interactions, including epithelial-fibroblast, epithelial-muscle and epithelial-nerve interactions.

Creation of High-Density and Low-Defect Molecular Films with a Flat-on Conformation by Interfacial Organization of Triphosphasumanene Trisulfides.

This paper focuses on the formation of high-density, low-defect monolayers of triphosphasumanene trisulfides, which are newly synthesized electronic and geometric Janus-type molecules, in a flat-on conformation. Although the molecules stack easily because of the developed π-conjugated plane, their application as a metal coating in a flat-on conformation via an interfacial molecular film enables the work function to be tuned. Surface pressure-area isotherms of the triphosphasumanene trisulfides show a two-dimensional phase transition at the air/water interface.