Publications by authors named "Hiroki Kosaka"
Tumor microscopic structure is crucial for determining properties such as cancer type, disease state (key for early diagnosis), and novel therapeutic strategies. Magnetic particle imaging is an early cancer diagnostic tool using magnetic nanoparticles as a tracer, which actualizes cancer theranostics in combination with hyperthermia treatment using the abilities of magnetic nanoparticles as a heat source. This study focuses on the microscopic structures associated with cancer cell distribution, the stromal compartment, and vascularization in different kinds of living tumors by analyzing the intratumor magnetic relaxation response of magnetic nanoparticles injected into the tumors.
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- Protein malnutrition leads to increased fat buildup in the liver of growing animals, triggering a rise in fibroblast growth factor 21 (FGF21) which helps protect the liver.
- Although FGF21 boosts thermogenesis in the body, it does not restore the secretion of very-low-density lipoprotein-triacylglycerol (VLDL-TAG) that is reduced during protein malnutrition.
- The protective effects of FGF21 against liver fat accumulation are linked to its role in thermogenesis, but this process is not the primary reason it prevents liver lipid buildup during protein malnutrition.
Article Synopsis
- The study investigates the long-term effects of low-dose hydrochlorothiazide (HCTZ) combined with either losartan (LOS) or telmisartan (TEL) on uric acid (UA) and glucose metabolism in hypertensive patients.
- A total of 59 patients were divided into two groups: one received LOS+HCTZ and the other TEL+HCTZ, with results showing both groups experienced significant decreases in blood pressure.
- While LOS+HCTZ did not affect UA or glucose levels, TEL+HCTZ led to higher UA levels and changes in glucose metabolism, particularly for patients with UA levels above 5.4 mg/dl.