Publications by authors named "Hiroki Kaifu"
Article Synopsis
- - Elevated nitric oxide (NO) production from inducible NO synthase (iNOS) in the esophagus is linked to increased mucosal damage in reflux esophagitis, while endothelial NO synthase (eNOS) and vascular endothelial growth factor (VEGF) levels didn't show a significant correlation.
- - A study measured mRNA levels of iNOS, eNOS, and VEGF in biopsy samples from 25 reflux esophagitis patients, finding a direct relationship between iNOS expression and the severity of esophagitis.
- - The findings suggest that targeting NO production could be a potential therapeutic strategy to mitigate mucosal injury in reflux esophagitis patients.
Background: Recent studies have shown that the number of patients with reflux esophagitis is increasing in Japan, but the prevalence and risk factors associated with reflux esophagitis in Japanese patients are not well defined.
Methods: By using all endoscopic records in the Katta General Hospital from April through to September 1999, we identified 392 patients. We examined the Los Angeles classification, peptic ulcer, gastric mucosal atrophy, hiatal hernia and other medical variable factors for their contribution to esophagitis in the patients.