Publications by authors named "Hiroki Hamagami"
Polysialic acid is an important glyco-epitope in vertebrate brains, while altered expressions of polySia and biosynthetic enzyme have been reported in brain diseases such as schizophrenia and depression. Recently, the binding between polySia and dopamine and the involvement of this in Akt signaling has been demonstrated. However, the molecular mechanism underlying the binding of polySia and dopamine remains unknown.
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- - The split-virus vaccine is a key defense against influenza but isn't fully effective; research has shown that Benifuuki green tea can enhance its immune response.
- - A compound called EGCG3"Me from the tea boosts the vaccine's ability to increase hemagglutination inhibition titers, suggesting a stronger immune reaction.
- - Increased expression of Toll-like receptor 5 (TLR5) in immune cells, linked to important immune mediators, indicates that EGCG3"Me helps improve the body’s immune response to the vaccine.
Article Synopsis
- The analysis of oligosaccharide shapes is key in glycobiology, and using NMR with atom-selectively C-labeled oligosaccharides gives more detailed insights into their structures.
- Traditional non-labeled oligosaccharides lack the depth of information provided by labeled ones, which can be limited in scope.
- This study introduces the synthesis of residue-selectively C- and H-labeled oligosaccharides, enhancing NMR measurements to reveal important information on their conformations, specifically in β(1,3)-glucan oligosaccharides.
The design of 6-azido-6-deoxy-l-idose for use as a hetero-bifunctional spacer is reported. The hemiacetal at one terminus is an equivalent of an aldehyde and can react with nucleophiles, such as amino groups and electron-rich aromatics. The azido group at the other terminus bio-orthogonally undergoes a Hüisgen [3+2] cycloaddition with an acetylene.
View Article and Find Full Text PDF(-)-Epigallocatechin-3-O-gallate (EGCG), the most abundant polyphenol in green tea, mediates the oxidative modification of proteins, generating protein carbonyls. However, the underlying molecular mechanism remains unclear. Here we analyzed the EGCG-derived intermediates generated upon incubation with the human serum albumin (HSA) and established that EGCG selectively oxidized the lysine residues via its oxidative deamination activity.
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