Publications by authors named "Hiroki Fukuhara"
Article Synopsis
- Rituximab (RIT) is commonly used to help kidney transplant recipients (KTRs) who are ABO-incompatible, but the effectiveness of valganciclovir (VGCV) in preventing cytomegalovirus (CMV) infection after RIT is uncertain.
- A study of 213 KTRs showed that those receiving VGCV had a significantly higher rate of CMV disease (23.5%) compared to those not receiving it (5.5%), though both groups experienced similar rates of CMV infection.
- The results suggest that insufficient VGCV dosage does not effectively lower CMV disease incidence post-RIT, but following a standard VGCV protocol may be beneficial
Article Synopsis
- The study aimed to determine whether low-dose rituximab treatment impacts the development of herpes zoster (shingles) in patients who received living kidney transplants.
- A total of 103 kidney transplant recipients were analyzed, with 50 having received rituximab; the incidence of herpes zoster was compared between those who did and did not receive the treatment.
- Results showed no significant difference in herpes zoster rates between the two groups, indicating that rituximab therapy does not affect herpes zoster development, while prior vaccination against varicella zoster may help prevent it.
Article Synopsis
- Sacral fractures can lead to lower urinary tract symptoms (LUTS) due to damage to the cauda equina, and there's limited understanding of how LUTS differs between high-energy and fragility fractures.
- This study analyzed eight patients with LUTS resulting from low-energy sacral fractures, comparing surgical and conservative treatment methods, and tracking their recovery.
- Results showed that most patients improved LUTS, with conservative treatment recommended as the first option, highlighting that surgical intervention may still be necessary if symptoms persist for several weeks.
Transplant ureteral stenosis (US) is a complication of kidney transplantation (KT) that sometimes adversely affects kidney function. Endoscopic treatment may be selected as the initial treatment; however, the recurrence rate is high. Ureteral reconstruction is necessary as a secondary treatment, but it is often difficult to identify the transplanted ureter due to reoperation; therefore, transplanted ureter and renal arteriovenous injury are intraoperative complications that should be noted.
View Article and Find Full Text PDFBackground: Kidney transplantation (KT) leads to body composition change, particularly increasing the fat mass. However, limited researches have focused on the long-term follow-up of these changes and factors influencing body composition after KT.
Methods: This study evaluated body composition in 31 adult KT recipients, measuring body mass index (BMI), the psoas muscle mass index (PMI) representing muscle mass, visceral and subcutaneous adipose tissue (VAT and SAT) representing fat mass, and skeletal muscle radiodensity (SMR) representing muscle quality before KT and at 2, 4, and 6 years posttransplantation using computed tomography.
(1) Background: Inflammatory responses induce the formation of both anti-tumor and pro-tumor neutrophils known as myeloid-derived suppressor cells (MDSCs). Intermittent intravesical infusion of (BCG) is an established cancer immunotherapy for non-muscle-invasive bladder cancer (NMIBC). However, the types of neutrophils induced via the inflammatory response to both tumor-bearing and BCG remain unclear.
View Article and Find Full Text PDFIntroduction: In this study, we evaluated whether SARS-CoV-2 mRNA vaccines induce anti-human leukocyte antigen (HLA) antibodies and anti- ABO blood type antibodies (ABOAb) in kidney transplant recipients (KTRs).
Methods: Sixty-three adult KTRs with functioning grafts who received two doses of the SARS-CoV-2 mRNA vaccine were enrolled in this cohort. Changes in anti-ABO blood type immunoglobulin IgM and IgG antibody titers, flow panel reactive antibody (PRA), de novo donor-specific anti-human leukocyte antigen antibodies (DSA), and kidney allograft function before and after vaccination were evaluated.
We evaluated the humoral and cellular immune responses and safety of the third severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine with a longer interval after the second vaccination in kidney transplant recipients (KTRs). We enrolled 54 kidney transplant recipients without a history of coronavirus disease 2019 (COVID-19), who received a third dose of the vaccine. We assessed anti-SARS-CoV-2 spike antibody and antigen-specific T cells using enzyme-linked immunospot (ELISpot) against the spike protein at baseline, after the second vaccination, and after the third vaccination.
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- This study investigates the success rates of second kidney transplants (TX2) compared to first ones (TX1) in Japanese patients, as data on TX2 outcomes are limited.
- Using data from 33 TX2 among 898 kidney transplants performed from 2010 to 2019, researchers applied survival analysis methods to assess death-censored graft survival (DCGS) and overall survival (OS) rates.
- The results indicated that while TX2 has comparable short-term survival rates to TX1, there were no significant differences found, suggesting that TX2 is a viable option for patients needing a second transplant.
Objectives: We evaluated whether the treatment history of low-dose rituximab affected safety profiles, and humoral and cellular responses induced by severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid vaccine in healthy controls and kidney transplant recipients.
Methods: We enrolled 10 healthcare workers as controls, 22 kidney transplant recipients with rituximab, and 36 kidney transplant recipients without rituximab without history of coronavirus disease 2019 who received two doses of vaccine. We assessed anti-severe acute respiratory syndrome coronavirus 2 spike antibody and the antigen-specific T cells using enzyme-linked immunospot against spike protein at baseline and after two doses of vaccine.
Purpose: Mitochondrial disease can affect many organs, including the brain, nerves, heart, liver, eyes, ears, pancreas, and kidneys. Kidney transplantation is a treatment option for renal failure due to mitochondrial disease; however, the prognosis of patients who undergo kidney transplantation for mitochondrial disease is unknown. Here we evaluated the outcomes of kidney transplant recipients with mitochondrial disease.
View Article and Find Full Text PDFBackground: Body composition changes 1 year after kidney transplant (KT) have been studied extensively. However, the number of reports on midterm body composition changes has been limited.
Methods: The medical records and computed tomography scans of 10 living kidney recipients (6 men, 4 women) before KT and at 1, 3, and 5 years post KT were analyzed.
Paste Aging Spontaneously Tunes TiO Nanoparticles into Reproducible Electrosprayed Photoelectrodes.
ACS Appl Mater Interfaces
November 2021
Article Synopsis
Background: Arteriovenous fistula (AVF) is the most preferred vascular access for hemodialysis patients, and early failure of AVF is one of the most avoidable complications of this procedure. We retrospectively evaluated whether adjuvant systemic heparinization just before arterial manipulation could reduce early failure of primary AVF.
Methods: Three hundred and fifty-six patients with end-stage renal failure who underwent primary AVF surgery from April 2009 to September 2020 were enrolled in this study.
Objectives: Our aim was to investigate effects of surgery on living donors' body composition and clarify factors related to it.
Materials And Methods: We evaluated preoperative computed tomography images of 335 living kidney donors (127 men, 209 women) to calculate 3 body composition parameters and changes with aging by sex: (1) skeletal muscle mass, quantified by skeletal muscle index; (2) fat distribution, calculated by visceral adipose tissue/subcutaneous adipose tissue ratio; and (3) muscle quality, quantified by intramuscular adipose tissue content. Thereafter, with pre- and postoperative computed tomography images from 75 living kidney donors (25 men, 50 women) after hand-assisted laparoscopic donor nephrectomy, we compared pre- and postoperative body composition changes.
Objectives: To create a new model for the prediction of overall survival in synchronous metastatic renal cell carcinoma.
Methods: Medical records of 158 patients with metastatic renal cell carcinoma diagnosed at the Yamagata University Hospital from August 2007 to February 2018 were reviewed. Among them, 77 with synchronous metastatic renal cell carcinoma were retrospectively analyzed using the univariate and multivariate analyses.
Article Synopsis
- * Results showed that about 20% of patients had long progression-free survival (PFS) of over 15 months in the first three lines of therapy, while minimal impact was seen in treatments beyond the third line.
- * Overall survival (OS) improved with triple-line therapy but not with quadruple-line therapy, indicating that while third-line treatments can be beneficial, fourth-line therapies do not provide additional survival advantages.
Objective: The CHOKAI and STONE scores are clinical prediction rules to predict ureteral stones in patients presenting with renal colic. Both systems contribute to reducing diagnostic radiation exposure; however, few studies have compared the two scoring systems. Therefore, we aimed to compare these systems and assess their diagnostic accuracy for ureteral stones.
View Article and Find Full Text PDFIntroduction: We investigated relationships between therapeutic outcomes of patients with emphysematous pyelonephritis (EPN) and changes in the Sequential Organ Failure Assessment (SOFA) score.
Materials And Methods: We retrospectively evaluated EPN patients treated in our hospitals using the SOFA score incorporated in the Sepsis-3 updated in 2016.
Results: Seventeen typical EPN patients were included in this study, and were treated with medical management with no drainage (n = 3), retrograde stenting (n = 10), or percutaneous drainage (n = 3).
Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) is phosphorylated and activated by mammalian target of rapamycin complex 1, which serves as a regulator of cell growth, cell survival, metastasis and angiogenesis in many types of cancer. The aim of this study was to evaluate the role of phosphorylated 4EBP1 (p4EBP1) in primary renal cell carcinoma (RCC) as a biomarker in metastatic RCC (mRCC) and non-mRCC cohorts. Primary tumor tissue from 254 non-mRCC and 60 mRCC patients were immunohistochemically stained for t4EBP1 and p4EBP1.
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- * Researchers analyzed data from 226 patients and found that factors like age, TrD-S, and stone location were significant predictors of whether patients would achieve a stone-free status after treatment.
- * The modified scoring system, called the Quadruple D score, showed better predictive accuracy for stone-free rates compared to the TrD-S alone.
Background: The objective was to explore the predictive markers of late recurrence (LR) > 5 years after curative nephrectomy for renal cell carcinoma (RCC).
Patients And Methods: We retrospectively examined the data from 303 patients with localized clear cell RCC treated surgically at our institution from 1993 to 2011. Activation of the eukaryotic initiation factor (eIF)4E-binding protein 1 (4EBP1)/eIF4E axis at the mammalian target of rapamycin complex 1 (mTORC1) was evaluated in the tumor specimens.