Publications by authors named "Hirokazu Tomishige"

Article Synopsis
  • A 67-year-old man with multiple liver metastases from metastatic colorectal cancer received TAS-102 combined with bevacizumab (Bmab) as a fifth-line chemotherapy treatment.* -
  • After 3 months on this regimen, imaging showed a 13% reduction in the size of the liver metastases.* -
  • The treatment was found to be safe and effective, with neutropenia being the most significant side effect, and the patient was able to continue for 6 months.*
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Background: Transplanted organs from female donors are associated with less favorable prognoses and outcomes. This study aimed to determine whether donor gender affects levels of serum terminal complement component C5a and oxidative stress in pediatric living related liver transplantation (LRLTx) recipients.

Material/methods: The subjects were 43 patients (20 males and 23 females) who underwent LRLTx during childhood (age range 1.

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A case of colouterine fistula caused by colonic diverticulitis that was successfully treated laparoscopically is presented. A 74-year-old woman visited us with lower abdominal discomfort and vaginal excretion with minor fecal contamination. Mild tenderness was observed in her lower abdomen.

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Article Synopsis
  • * The authors present their experience with 6 cases of LLR involving major hepatic vein resection, detailing the types of surgeries performed, tumor sizes, operating times, blood loss, and hospital stays, all with no mortality and minimal complications.
  • * They propose a series of specific steps for conducting the procedure, leveraging the benefits of laparoscopy for better visibility and control during liver transection and vein division.
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Aim: To assess clinical outcomes of laparoscopic hepatectomy (LH) in patients with a history of upper abdominal surgery and repeat hepatectomy.

Methods: This study compared the perioperative courses of patients receiving LH at our institution that had or had not previously undergone upper abdominal surgery. Of the 80 patients who underwent LH, 22 had prior abdominal surgeries, including hepatectomy (n = 12), pancreatectomy (n = 3), cholecystectomy and common bile duct excision (n = 1), splenectomy (n = 1), total gastrectomy (n = 1), colectomy with the involvement of transverse colon (n = 3), and extended hysterectomy with extensive lymph-node dissection up to the upper abdomen (n = 1).

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Article Synopsis
  • - Hepatocellular carcinoma (HCC) is the leading primary liver cancer, often linked to chronic liver disease, making treatment complicated and reliant on various factors such as liver function and HCC stage.
  • - Liver resection (LR) is an effective treatment for HCC, with advances in imaging and surgical techniques improving 5-year survival rates to 38-61%, but it's only suitable for less than 30% of patients, and recurrence rates are high at around 80% within 5 years.
  • - Recent developments include enhanced preoperative planning with 3D imaging, the potential for laparoscopic surgery, and innovative therapies that could broaden the application of LR, alongside concepts like "bridging LR" and "sal
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Article Synopsis
  • Hepatocellular carcinoma (HCC) is the most common form of liver cancer, and its treatment is complicated by factors like the patient's liver condition, cancer stage, and overall health.
  • Liver resection (LR) is a highly effective treatment option, especially for early-stage HCC, with considerable survival rates improved by better liver function assessments and surgical techniques.
  • Liver transplantation (LT) is ideal for removing tumors and damaged liver tissue but is limited by graft availability and strict eligibility criteria, prompting interest in expanding donor options and exploring combined treatments with LR and LT.
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The location of an ingested foreign object is often difficult to determine by X-ray if gastric air bubbles are not clear in the image. Methods that provide negative contrast can facilitate precise object localization, which is important for object retrieval and treatment of the patient. This case report describes a male child, 2 years and 2 mo of age, who accidentally swallowed a lithium battery while playing at home.

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Pure laparoscopic hepatectomy is a less invasive procedure than conventional open hepatectomy for the resection of hepatic lesions. Increases in experiences with the technique, in combination with advances in technology, have promoted the popularity of pure laparoscopic hepatectomy. However, indications for usage and potential contraindications of the procedure remain unresolved.

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Aim: To study our novel caudal approach laparoscopic posterior-sectionectomy with parenchymal transection prior to mobilization under laparoscopy-specific view.

Methods: Points of the procedure are: (1) Patients are put in left lateral position and posterior sector is not mobilized; (2) Glissonian pedicle of the sector is encircled and clamped extra-hepatically and divided afterward during the transection; (3) Dissection of inferior vena cava (IVC) anterior wall behind the liver is started from caudal. Simultaneously, liver transection is performed to search right hepatic vein (RHV) from caudal; (4) Liver transection proceeds to the bifurcation of the vessels from caudal to cranial, exposing the surfaces of IVC and RHV.

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Background: Main indications for liver transplantation in the pediatric population include biliary atresia and inherited metabolic diseases. The present study evaluated whether there are differences between pediatric patients undergoing living-related liver transplantation due to the two diseases in terms of their oxidative and immunological status during their regular outpatient follow-up visits.

Material And Methods: A clinical outpatient study measuring serum oxidative stress index (calculated as serum oxidant/antioxidant ratio, in the form of serum total hydroperoxide/serum biological antioxidative potential), serum terminal complement component 5a, as an indicator of complement activity and immunological status, and transforming growth factor-ß1, as a marker of liver fibrosis, in 16 patients (6 males and 10 females, 2.

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Solitary necrotic nodule of the liver is a rare benign lesion with a completely necrotic core and a hyalinized fibrotic capsule containing elastic fibers. The pathogenetic mechanism is still unclear. We here describe a case of SNN, whose central reticulin fibers within the nodule suggest the origin as hepatocellular carcinoma or other hepatocyte-origin tumors, treated with laparoscopic anatomical segmentectomy of the liver.

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Background: ABO-incompatible liver transplantation (LTx) is becoming more common in response to the paucity of liver allografts. Several studies have expressed concern about the effect of ABO compatibility on graft survival.

Purpose: To evaluate the differences in serum cytokine levels between ABO-incompatible (ABO-i) and ABO-compatible (ABO-c; includes ABO-compatible and identical) pediatric LTx recipients during regular outpatient follow-up.

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Background: Oxidative stress has been suspected to influence graft survival and prognosis in pediatric recipients of living related liver transplantation (LRLT).

Purpose: We determined the oxidative status of pediatric LRLT recipients during their regular outpatient follow-up visits, and looked for a relationship between oxidative status and post-liver transplantation (post-LTx) duration.

Patients: The study included 43 patients (20 males and 23 females) between the ages of 1.

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Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25-dihydroxyvitamin D.

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The authors encountered a 2-year-old-girl with adrenocortical carcinoma who underwent percutaneous ethanol injection therapy (PEIT) for liver metastasis. The patient had functional adrenocortical carcinoma diagnosed and underwent excision of the tumor in the right adrenal gland. Because liver metastasis was detected 11 months after surgery, the patient underwent PEIT under general anesthesia.

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