PET Tracer F-Fluciclovine Can Detect Histologically Proven Bone Metastatic Lesions: A Preclinical Study in Rat Osteolytic and Osteoblastic Bone Metastasis Models.

F-Fluciclovine (-1-amino-3-F-fluorocyclobutanecarboxylic acid; -F-FACBC) is a positron emission tomography (PET) tracer for diagnosing cancers (e.g., prostate and breast cancer).

Fasting Enhances the Contrast of Bone Metastatic Lesions in F-Fluciclovine-PET: Preclinical Study Using a Rat Model of Mixed Osteolytic/Osteoblastic Bone Metastases.

F-fluciclovine (-1-amino-3-F-fluorocyclobutanecarboxylic acid) is an amino acid positron emission tomography (PET) tracer used for cancer staging (e.g., prostate and breast).

Assessment of Amino Acid/Drug Transporters for Renal Transport of [F]Fluciclovine (anti-[F]FACBC) in Vitro.

[F]Fluciclovine (-1-amino-3-[F]fluorocyclobutanecarboxylic acid; -[F]FACBC), a positron emission tomography tracer used for the diagnosis of recurrent prostate cancer, is transported via amino acid transporters (AATs) with high affinity (: 97-230 μM). However, the mechanism underlying urinary excretion is unknown. In this study, we investigated the involvement of AATs and drug transporters in renal [F]fluciclovine reuptake.